"Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
|Transcription Factor 4
- Transcription Factor 4
- TCF4 Transcription Factor
- Transcription Factor, TCF4
- TCF-4 Transcription Factor
- TCF 4 Transcription Factor
- Transcription Factor, TCF-4
- TCF-4 Protein
- TCF 4 Protein
Below are MeSH descriptors whose meaning is more general than "Transcription Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor 4".
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Below are the most recent publications written about "Transcription Factor 4" by people in Profiles.
Development of Type 2 Innate Lymphoid Cells Is Selectively Inhibited by Sustained E Protein Activity. Immunohorizons. 2019 12 18; 3(12):593-605.
Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors. J Exp Med. 2019 04 01; 216(4):884-899.
Stimulation of ß-catenin and colon cancer cell growth by the KDM4B histone demethylase. Int J Oncol. 2014 Apr; 44(4):1341-8.
Reg4-induced mitogenesis involves Akt-GSK3ß-ß-Catenin-TCF-4 signaling in human colorectal cancer. Mol Carcinog. 2014 Feb; 53 Suppl 1:E169-80.