"Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
| Descriptor ID |
D000073940
|
| MeSH Number(s) |
D12.776.260.108.092.937 D12.776.930.125.500.937
|
| Concept/Terms |
Transcription Factor 4- Transcription Factor 4
- TCF4 Transcription Factor
- Transcription Factor, TCF4
- TCF-4 Transcription Factor
- TCF 4 Transcription Factor
- Transcription Factor, TCF-4
- TCF-4 Protein
- TCF 4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Transcription Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor 4".
This graph shows the total number of publications written about "Transcription Factor 4" by people in this website by year, and whether "Transcription Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Transcription Factor 4" by people in Profiles.
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Development of Type 2 Innate Lymphoid Cells Is Selectively Inhibited by Sustained E Protein Activity. Immunohorizons. 2019 12 18; 3(12):593-605.
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Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors. J Exp Med. 2019 04 01; 216(4):884-899.
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Stimulation of ß-catenin and colon cancer cell growth by the KDM4B histone demethylase. Int J Oncol. 2014 Apr; 44(4):1341-8.
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Reg4-induced mitogenesis involves Akt-GSK3ß-ß-Catenin-TCF-4 signaling in human colorectal cancer. Mol Carcinog. 2014 Feb; 53 Suppl 1:E169-80.