Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.
Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol. 2018 04 01; 314(4):H693-H703.
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Alzheimer Disease
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Alzheimer Disease
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Animals
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Animals
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Behavior, Animal
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Behavior, Animal
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Blood-Brain Barrier
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Blood-Brain Barrier
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Cell Line
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Cell Line
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Cognition
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Cognition
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Dementia, Vascular
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Dementia, Vascular
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Disease Models, Animal
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Disease Models, Animal
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Female
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Female
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Male
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Male
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Matrix Metalloproteinase 9
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Matrix Metalloproteinase 9
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Mechanistic Target of Rapamycin Complex 1
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Mechanistic Target of Rapamycin Complex 1
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Mice, Inbred C57BL
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Knockout
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Protein Kinase Inhibitors
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Protein Kinase Inhibitors
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Receptors, LDL
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Receptors, LDL
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Sirolimus
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Sirolimus
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Tight Junction Proteins
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Tight Junction Proteins
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Tight Junctions
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Tight Junctions
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TOR Serine-Threonine Kinases
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TOR Serine-Threonine Kinases