Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases.
Brown KM, Suvorova E, Farrell A, McLain A, Dittmar A, Wiley GB, Marth G, Gaffney PM, Gubbels MJ, White M, Blader IJ. Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases. PLoS Pathog. 2014 Jun; 10(6):e1004180.
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Activin Receptors, Type I
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Activin Receptors, Type I
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Animals
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Animals
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Base Sequence
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Base Sequence
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Benzodioxoles
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Benzodioxoles
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Catalytic Domain
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Catalytic Domain
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DNA, Protozoan
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DNA, Protozoan
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Drug Resistance
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Drug Resistance
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Genome, Protozoan
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Genome, Protozoan
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Host-Parasite Interactions
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Host-Parasite Interactions
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1
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Imidazoles
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Imidazoles
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Mice
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Mice
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Mice, Inbred C57BL
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Mice, Inbred C57BL
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Mitogen-Activated Protein Kinase 1
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Mitogen-Activated Protein Kinase 1
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Protozoan Proteins
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Protozoan Proteins
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Pyridines
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Pyridines
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Sequence Analysis, DNA
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Sequence Analysis, DNA
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Signal Transduction
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Signal Transduction
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Toxoplasma
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Toxoplasma