Distinctive roles for 2',5'-oligoadenylate synthetases and double-stranded RNA-dependent protein kinase R in the in vivo antiviral effect of an adenoviral vector expressing murine IFN-beta.
Al-Khatib K, Williams BR, Silverman RH, Halford W, Carr DJ. Distinctive roles for 2',5'-oligoadenylate synthetases and double-stranded RNA-dependent protein kinase R in the in vivo antiviral effect of an adenoviral vector expressing murine IFN-beta. J Immunol. 2004 May 01; 172(9):5638-47.
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2',5'-Oligoadenylate Synthetase
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2',5'-Oligoadenylate Synthetase
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Adenoviridae
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Adenoviridae
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Adjuvants, Immunologic
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Adjuvants, Immunologic
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Administration, Topical
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Administration, Topical
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Animals
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Animals
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Antiviral Agents
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Antiviral Agents
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CD8-Positive T-Lymphocytes
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CD8-Positive T-Lymphocytes
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Cell Migration Inhibition
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Cell Migration Inhibition
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Cells, Cultured
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Cells, Cultured
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eIF-2 Kinase
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eIF-2 Kinase
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Female
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Female
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Genetic Vectors
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Genetic Vectors
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Green Fluorescent Proteins
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Green Fluorescent Proteins
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Herpesvirus 1, Human
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Herpesvirus 1, Human
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Interferon-beta
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Interferon-beta
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Interferon-gamma
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Interferon-gamma
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Keratitis, Herpetic
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Keratitis, Herpetic
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Killer Cells, Natural
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Killer Cells, Natural
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Luminescent Proteins
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Luminescent Proteins
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Mice
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Mice
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Mice, Inbred C57BL
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Mice, Inbred C57BL
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Mice, Inbred ICR
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Mice, Inbred ICR
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Mice, Knockout
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Mice, Knockout
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Survival Analysis
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Survival Analysis
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Trigeminal Ganglion
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Trigeminal Ganglion
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Virus Replication
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Virus Replication