Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.
Terzyan SS, Shen T, Liu X, Huang Q, Teng P, Zhou M, Hilberg F, Cai J, Mooers BHM, Wu J. Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J Biol Chem. 2019 07 05; 294(27):10428-10437.
-
Animals
-
Animals
-
Binding Sites
-
Binding Sites
-
Cell Line, Tumor
-
Cell Line, Tumor
-
Crystallography, X-Ray
-
Crystallography, X-Ray
-
Drug Resistance, Neoplasm
-
Drug Resistance, Neoplasm
-
Humans
-
Humans
-
Hydrophobic and Hydrophilic Interactions
-
Hydrophobic and Hydrophilic Interactions
-
Indoles
-
Indoles
-
Mice
-
Mice
-
Molecular Dynamics Simulation
-
Molecular Dynamics Simulation
-
Mutagenesis, Site-Directed
-
Mutagenesis, Site-Directed
-
Piperidines
-
Piperidines
-
Protein Kinase Inhibitors
-
Protein Kinase Inhibitors
-
Protein Structure, Tertiary
-
Protein Structure, Tertiary
-
Proto-Oncogene Proteins c-ret
-
Proto-Oncogene Proteins c-ret
-
Quinazolines
-
Quinazolines
-
Recombinant Proteins
-
Recombinant Proteins