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Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.
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Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.
Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J Biol Chem. 2019 07 05; 294(27):10428-10437.
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subject areas
Animals
Animals
Binding Sites
Binding Sites
Cell Line, Tumor
Cell Line, Tumor
Crystallography, X-Ray
Crystallography, X-Ray
Drug Resistance, Neoplasm
Drug Resistance, Neoplasm
Humans
Humans
Hydrophobic and Hydrophilic Interactions
Hydrophobic and Hydrophilic Interactions
Indoles
Indoles
Mice
Mice
Molecular Dynamics Simulation
Molecular Dynamics Simulation
Mutagenesis, Site-Directed
Mutagenesis, Site-Directed
Piperidines
Piperidines
Protein Kinase Inhibitors
Protein Kinase Inhibitors
Protein Structure, Tertiary
Protein Structure, Tertiary
Proto-Oncogene Proteins c-ret
Proto-Oncogene Proteins c-ret
Quinazolines
Quinazolines
Recombinant Proteins
Recombinant Proteins
authors with profiles
Blaine H Mooers