"alpha-2-Antiplasmin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the serpin superfamily found in plasma that inhibits the lysis of fibrin clots which are induced by plasminogen activator. It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. It is the principal plasmin inactivator in blood, rapidly forming a very stable complex with plasmin.
| Descriptor ID |
D000979
|
| MeSH Number(s) |
D12.644.861.050 D12.776.124.790.106.090 D12.776.377.715.085.090 D12.776.395.080 D12.776.872.050
|
| Concept/Terms |
alpha-2-Antiplasmin- alpha-2-Antiplasmin
- Serpin F2
- alpha-2 Antiplasmin
- alpha 2 Antiplasmin
- alpha 2-Plasmin Inhibitor
- alpha 2 Plasmin Inhibitor
- alpha(2)-Plasmin Inhibitor
|
Below are MeSH descriptors whose meaning is more general than "alpha-2-Antiplasmin".
Below are MeSH descriptors whose meaning is more specific than "alpha-2-Antiplasmin".
This graph shows the total number of publications written about "alpha-2-Antiplasmin" by people in this website by year, and whether "alpha-2-Antiplasmin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha-2-Antiplasmin" by people in Profiles.
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Age-based difference in activation markers of coagulation and fibrinolysis in extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2014 Jun; 15(5):e198-205.
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Enhancement of fibrinolysis by inhibiting enzymatic cleavage of precursor a2-antiplasmin. J Thromb Haemost. 2011 May; 9(5):987-96.
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Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design. Biochemistry. 2009 Jun 16; 48(23):5149-58.
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Evidence that alpha2-antiplasmin becomes covalently ligated to plasma fibrinogen in the circulation: a new role for plasma factor XIII in fibrinolysis regulation. J Thromb Haemost. 2008 Sep; 6(9):1565-70.
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Why alpha-antiplasmin must be converted to a derivative form for optimal function. J Thromb Haemost. 2007 Oct; 5(10):2095-104.
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Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer. Cancer Biol Ther. 2007 Nov; 6(11):1691-9.
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The effect of a single nucleotide polymorphism on human alpha 2-antiplasmin activity. Blood. 2007 Jun 15; 109(12):5286-92.
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Alpha2-antiplasmin: potential therapeutic roles in fibrin survival and removal. Curr Med Chem Cardiovasc Hematol Agents. 2004 Oct; 2(4):303-10.
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A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion. Blood. 2004 May 15; 103(10):3783-8.
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Crosslinking of alpha 2-antiplasmin to fibrin. Ann N Y Acad Sci. 2001; 936:335-9.