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Anthony W Burgett

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
AddressCPB 313
1110 N Stonewall Ave
Oklahoma City OK 73117
Phone405/271-6593 ext 47211
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    Collapse Research 
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    R01AI154274     (BURGETT, ANTHONY WG)Apr 8, 2021 - Mar 31, 2026
    NIH
    Cellular Mechanism of Oxysterol-Binding Protein (OSBP) in Viral Proliferation: A Chemical Biology Approach
    Role: Principal Investigator
    R21CA204706     (BURGETT, ANTHONY WG)May 23, 2016 - Apr 30, 2019
    NIH
    Mass Spectrometry Detection of Drugs in Single Bladder Cancer Cells from Patients
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Subramaniyan B, Larabee JL, Bodas M, Moore AR, Burgett AWG, Papin JF, Walters MS. Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication. Am J Respir Cell Mol Biol. 2023 Sep; 69(3):367-370. PMID: 37655875; PMCID: PMC10503309.
      Citations:    Fields:    Translation:HumansCells
    2. Gardner ED, Johnson BP, Dimas DA, McClurg HE, Severance ZC, Burgett AW, Singh S. Unlocking New Prenylation Modes: Azaindoles as a New Substrate Class for Indole Prenyltransferases. ChemCatChem. 2023 Oct 06; 15(19). PMID: 37954549; PMCID: PMC10634513.
      Citations:    
    3. Severance ZC, Nu?ez JI, Le-McClain AT, Malinky CA, Bensen RC, Fogle RS, Manginelli GW, Sakers SH, Falcon EC, Bui RH, Snead KJ, Bourne CR, Burgett AWG. Structure-Activity Relationships of Ligand Binding to Oxysterol-Binding Protein (OSBP) and OSBP-Related Protein 4. J Med Chem. 2023 03 23; 66(6):3866-3875. PMID: 36916802.
      Citations:    Fields:    Translation:HumansCells
    4. Subramaniyan B, Larabee JL, Bodas M, Moore AR, Burgett AWG, Myers DA, Georgescu C, Wren JD, Papin JF, Walters MS. Characterization of the SARS-CoV-2 Host Response in Primary Human Airway Epithelial Cells from Aged Individuals. Viruses. 2021 08 12; 13(8). PMID: 34452468.
      Citations: 9     Fields:    Translation:HumansCells
    5. Bensen RC, Gunay G, Finneran MC, Jhingan I, Acar H, Burgett AWG. Small Molecule Targeting of Oxysterol-Binding Protein (OSBP)-Related Protein 4 and OSBP Inhibits Ovarian Cancer Cell Proliferation in Monolayer and Spheroid Cell Models. ACS Pharmacol Transl Sci. 2021 Apr 09; 4(2):744-756. PMID: 33860198.
      Citations: 9     
    6. Bensen RC, Standke SJ, Colby DH, Kothapalli NR, Le-McClain AT, Patten MA, Tripathi A, Heinlen JE, Yang Z, Burgett AWG. Single Cell Mass Spectrometry Quantification of Anticancer Drugs: Proof of Concept in Cancer Patients. ACS Pharmacol Transl Sci. 2021 Feb 12; 4(1):96-100. PMID: 33615163.
      Citations: 7     
    7. Terzyan SS, Nguyen LT, Burgett AWG, Heroux A, Smith CA, You Y, Hanigan MH. Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site. J Biol Chem. 2021 Jan-Jun; 296:100066. PMID: 33187988.
      Citations: 6     Fields:    Translation:HumansCells
    8. Gardner ED, Dimas DA, Finneran MC, Brown SM, Burgett AW, Singh S. Indole C6 Functionalization of Tryprostatin B Using Prenyltransferase CdpNPT. Catalysts. 2020 Nov; 10(11). PMID: 33643664.
      Citations: 3     
    9. Roberts BL, Severance ZC, Bensen RC, Le-McClain AT, Malinky CA, Mettenbrink EM, Nuñez JI, Reddig WJ, Blewett EL, Burgett AWG. Differing activities of oxysterol-binding protein (OSBP) targeting anti-viral compounds. Antiviral Res. 2019 10; 170:104548. PMID: 31271764.
      Citations: 13     Fields:    Translation:HumansCells
    10. Pan N, Standke SJ, Kothapalli NR, Sun M, Bensen RC, Burgett AWG, Yang Z. Quantification of Drug Molecules in Live Single Cells Using the Single-Probe Mass Spectrometry Technique. Anal Chem. 2019 07 16; 91(14):9018-9024. PMID: 31246408.
      Citations: 14     Fields:    Translation:HumansCells
    11. Standke SJ, Colby DH, Bensen RC, Burgett AWG, Yang Z. Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells. J Vis Exp. 2019 06 21; (148). PMID: 31282898.
      Citations: 4     Fields:    Translation:HumansCells
    12. Bandari C, Scull EM, Bavineni T, Nimmo SL, Gardner ED, Bensen RC, Burgett AW, Singh S. FgaPT2, a biocatalytic tool for alkyl-diversification of indole natural products. Medchemcomm. 2019 Aug 01; 10(8):1465-1475. PMID: 31534661.
      Citations: 9     
    13. Standke SJ, Colby DH, Bensen RC, Burgett AWG, Yang Z. Mass Spectrometry Measurement of Single Suspended Cells Using a Combined Cell Manipulation System and a Single-Probe Device. Anal Chem. 2019 02 05; 91(3):1738-1742. PMID: 30644722.
      Citations: 21     Fields:    Translation:HumansCells
    14. Roberts BL, Severance ZC, Bensen RC, Le AT, Kothapalli NR, Nuñez JI, Ma H, Wu S, Standke SJ, Yang Z, Reddig WJ, Blewett EL, Burgett AWG. Transient Compound Treatment Induces a Multigenerational Reduction of Oxysterol-Binding Protein (OSBP) Levels and Prophylactic Antiviral Activity. ACS Chem Biol. 2019 02 15; 14(2):276-287. PMID: 30576108.
      Citations: 13     Fields:    Translation:HumansCells
    15. Harper AR, Le AT, Mather T, Burgett A, Berry W, Summers JA. Design, synthesis, and ex vivo evaluation of a selective inhibitor for retinaldehyde dehydrogenase enzymes. Bioorg Med Chem. 2018 12 01; 26(22):5766-5779. PMID: 30409702.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    16. Terzyan SS, Burgett AW, Heroux A, Smith CA, Mooers BH, Hanigan MH. Human ?-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem. 2015 Jul 10; 290(28):17576-86. PMID: 26013825.
      Citations: 18     Fields:    Translation:HumansCells
    17. Pan N, Rao W, Kothapalli NR, Liu R, Burgett AW, Yang Z. The single-probe: a miniaturized multifunctional device for single cell mass spectrometry analysis. Anal Chem. 2014 Oct 07; 86(19):9376-80. PMID: 25222919.
      Citations: 79     Fields:    Translation:HumansCells
    18. Burgett AW, Poulsen TB, Wangkanont K, Anderson DR, Kikuchi C, Shimada K, Okubo S, Fortner KC, Mimaki Y, Kuroda M, Murphy JP, Schwalb DJ, Petrella EC, Cornella-Taracido I, Schirle M, Tallarico JA, Shair MD. Natural products reveal cancer cell dependence on oxysterol-binding proteins. Nat Chem Biol. 2011 Aug 07; 7(9):639-47. PMID: 21822274.
      Citations: 86     Fields:    Translation:HumansCells
    19. Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL. Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2074-9. PMID: 17287337.
      Citations: 16     Fields:    Translation:AnimalsCells
    20. Wang G, Shang L, Burgett AW, Harran PG, Wang X. Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2068-73. PMID: 17287350.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    21. Burgett AW, Li Q, Wei Q, Harran PG. A concise and flexible total synthesis of (-)-diazonamide A. Angew Chem Int Ed Engl. 2003 Oct 20; 42(40):4961-6. PMID: 14579451.
      Citations: 23     Fields:    Translation:Cells
    22. Li J, Burgett AW, Esser L, Amezcua C, Harran PG. Total Synthesis of Nominal Diazonamides-Part 2: On the True Structure and Origin of Natural Isolates Funding provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), the Robert A. Welch Foundation, and the Advanced Research Program of the Texas Higher Education Coordinating Board. We are grateful to Professor Michael Roth for his time, insight, and advice. Angew Chem Int Ed Engl. 2001 Dec 17; 40(24):4770-4773. PMID: 12404412.
      Citations: 32     Fields:    
    23. Li J, Burgett AW, Esser L, Amezcua C, Harran PG. Preview. Angew Chem Int Ed Engl. 2001 Dec 17; 40(24):4776. PMID: 12404413.
      Citations:    Fields:    
    24. Li J, Chen X, Burgett AWG, Harran PG. Synthetic seco Forms of (-)-Diazonamide A. Angew Chem Int Ed Engl. 2001 Jul 16; 40(14):2682-2685. PMID: 29712335.
      Citations: 2     Fields:    
    25. Li J, Chen X, Burgett AW, Harran PG. Synthetic seco Forms of (-)-Diazonamide A We thank Prof. Michael Roth for advice and insight and Ms. Susan Jeong for invaluable experimental assistance. Funding was provided by the NIH (RO1-GM60591), the NSF (CAREER 9984282), the Howard Hughes Medical Institute (junior faculty support), and the Robert A. Welch Foundation. Angew Chem Int Ed Engl. 2001 Jul 16; 40(14):2682-2685. PMID: 11458372.
      Citations:    Fields:    
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