Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers.

Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers. Clin Cancer Res. 2018 12 15; 24(24):6459-6470.

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subject areas

Animals
Breast Neoplasms
CDC2 Protein Kinase
Cell Cycle Proteins
Cell Line, Tumor
Disease Models, Animal
DNA Damage
Female
Gene Expression Regulation, Neoplastic
Genes, BRCA1
Genes, BRCA2
Genes, Reporter
Humans
Mice
Mutation
Neoplasm Proteins
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases
Promoter Regions, Genetic
Synthetic Lethal Mutations
Xenograft Model Antitumor Assays

authors with profiles

Julio C. Morales