"Transducin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodopsin to cyclic GMP phosphodiesterase and is pivotal in the visual excitation process. Activation of rhodopsin on the outer membrane of rod and cone cells causes GTP to bind to transducin followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of transducin. The alpha subunit-GTP complex activates the cyclic GMP phosphodiesterase which catalyzes the hydrolysis of cyclic GMP to 5'-GMP. This leads to closure of the sodium and calcium channels and therefore hyperpolarization of the rod cells.
| Descriptor ID |
D015293
|
| MeSH Number(s) |
D08.811.277.040.330.300.200.800 D12.644.360.360.940 D12.776.157.325.332.940 D12.776.476.375.940 D12.776.543.325.800
|
| Concept/Terms |
Transducin- Transducin
- Transducin G-Protein (Gt)
- Gt, Transducin G-Protein
- G-Protein Gt, Transducin
- Gt, Transducin G Protein
- Transducin G-Protein Gt
- G-Protein, Inhibitory Gt
- G Protein, Inhibitory Gt
- Gt G-Protein, Inhibitory
- Inhibitory Gt G-Protein
gamma-Transducin- gamma-Transducin
- gamma Transducin
- Transducin, gamma Subunit
- gamma Subunit Transducin
beta-Transducin- beta-Transducin
- beta Transducin
- Transducin, beta Subunit
- beta Subunit Transducin
alpha-Transducin- alpha-Transducin
- alpha Transducin
- Transducin, alpha Subunit
- alpha Subunit Transducin
|
Below are MeSH descriptors whose meaning is more general than "Transducin".
Below are MeSH descriptors whose meaning is more specific than "Transducin".
This graph shows the total number of publications written about "Transducin" by people in this website by year, and whether "Transducin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 1 | 1 | 2 |
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Below are the most recent publications written about "Transducin" by people in Profiles.
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Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa. Int Forum Allergy Rhinol. 2013 Jun; 3(6):450-7.
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CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration. Invest Ophthalmol Vis Sci. 2012 Mar 01; 53(3):1117-29.
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Mislocalization of oligomerization-incompetent RDS is associated with mislocalization of cone opsins and cone transducin. Adv Exp Med Biol. 2012; 723:657-62.
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Phosphoinositide 3-kinase signaling in retinal rod photoreceptors. Invest Ophthalmol Vis Sci. 2011 Aug 11; 52(9):6355-62.
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Early-onset, slow progression of cone photoreceptor dysfunction and degeneration in CNG channel subunit CNGB3 deficiency. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3557-66.
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Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. Biochemistry. 2009 Jun 23; 48(24):5563-72.
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Effects of low AIPL1 expression on phototransduction in rods. Invest Ophthalmol Vis Sci. 2006 May; 47(5):2185-94.
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RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1177-84.
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Bright cyclic light accelerates photoreceptor cell degeneration in tubby mice. Neurobiol Dis. 2006 Mar; 21(3):468-77.
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Cholesterol-dependent association of caveolin-1 with the transducin alpha subunit in bovine photoreceptor rod outer segments: disruption by cyclodextrin and guanosine 5'-O-(3-thiotriphosphate). Biochemistry. 2003 Jul 08; 42(26):7892-903.