Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner.

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. J Biol Chem. 2012 Jun 22; 287(26):22408-17.

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subject areas

Apoptosis
Cell Line, Tumor
Cyanides
Dose-Response Relationship, Drug
Gene Expression Regulation, Neoplastic
Glutathione
Guanidines
Humans
NADP
Niacinamide
Nicotinamide Phosphoribosyltransferase
Oxidation-Reduction
Pentosyltransferases
Reactive Oxygen Species
Superoxides
Tumor Suppressor Protein p53

authors with profiles

Naoko Takebe