"Thrombospondin 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An extracellular matrix glycoprotein from platelets and a variety of normal and transformed cells of both mesenchymal and epithelial origin. Thrombospondin-1 is believed to play a role in cell migration and proliferation, during embryogenesis and wound repair. Also, it has been studied for its use as a potential regulator of tumor growth and metastasis.
| Descriptor ID |
D019700
|
| MeSH Number(s) |
D12.776.395.550.895.800 D12.776.543.550.895.800
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Thrombospondin 1".
Below are MeSH descriptors whose meaning is more specific than "Thrombospondin 1".
This graph shows the total number of publications written about "Thrombospondin 1" by people in this website by year, and whether "Thrombospondin 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thrombospondin 1" by people in Profiles.
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Glioblastoma remodelling of human neural circuits decreases survival. Nature. 2023 May; 617(7961):599-607.
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New methodologies to accurately assess circulating active transforming growth factor-ß1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices. Transl Res. 2018 02; 192:15-29.
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The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis. PLoS Genet. 2013; 9(12):e1004031.
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Thrombospondin-1: the good, the bad, and the complicated. Circ Res. 2013 Dec 06; 113(12):1272-4.
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Angiotensin II sustains brain inflammation in mice via TGF-beta. J Clin Invest. 2010 Aug; 120(8):2782-94.
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In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1. PLoS One. 2009 Aug 12; 4(8):e6608.