"Thrombospondins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
| Descriptor ID |
D019699
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| MeSH Number(s) |
D12.776.395.550.895 D12.776.543.550.895
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thrombospondins".
Below are MeSH descriptors whose meaning is more specific than "Thrombospondins".
This graph shows the total number of publications written about "Thrombospondins" by people in this website by year, and whether "Thrombospondins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 2 | 2 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thrombospondins" by people in Profiles.
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Prolactin-Induced Protein facilitates corneal wound healing. Exp Eye Res. 2022 Dec; 225:109300.
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Engineering high-potency R-spondin adult stem cell growth factors. Mol Pharmacol. 2015; 87(3):410-20.
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Microarray analysis of insulin-like growth factor-I-induced changes in messenger ribonucleic acid expression in cultured porcine granulosa cells: possible role of insulin-like growth factor-I in angiogenesis. J Anim Sci. 2009 Jun; 87(6):1921-33.
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ADAMTS13: what it does, how it works, and why it's important. Transfusion. 2009 Feb; 49(2):196-8.
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Platelet membrane topography: colocalization of thrombospondin and fibrinogen with the glycoprotein IIb-IIIa complex. Blood. 1985 Oct; 66(4):926-34.