"CD40 Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.
| Descriptor ID |
D023201
|
| MeSH Number(s) |
D12.644.276.374.750.124 D12.776.395.550.185 D12.776.467.374.750.124 D12.776.543.550.198 D23.529.374.750.124
|
| Concept/Terms |
CD40 Ligand- CD40 Ligand
- gp39 Antigen, T-Cell
- T-Cell gp39 Antigen
- gp39 Antigen, T Cell
- CD40L
- Tumor Necrosis Factor Ligand Superfamily Member 5
- Antigen, CD154
- CD154 Antigen
- T-B Cell Activating Molecule
- TNF Superfamily, Member 5
- CD154 Antigens
- Antigens, CD154
|
Below are MeSH descriptors whose meaning is more general than "CD40 Ligand".
Below are MeSH descriptors whose meaning is more specific than "CD40 Ligand".
This graph shows the total number of publications written about "CD40 Ligand" by people in this website by year, and whether "CD40 Ligand" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 2 | 2 |
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Below are the most recent publications written about "CD40 Ligand" by people in Profiles.
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Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production. Eur J Immunol. 2015 Feb; 45(2):612-23.
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Proinflammatory adaptive cytokine and shed tumor necrosis factor receptor levels are elevated preceding systemic lupus erythematosus disease flare. Arthritis Rheumatol. 2014 Jul; 66(7):1888-99.
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Co-stimulatory molecules as targets for treatment of lupus. Clin Immunol. 2013 Sep; 148(3):369-75.
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CD40L-null NKT cells provide B cell help for specific antibody responses. Vaccine. 2011 Nov 15; 29(49):9132-6.
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Reduction of CD1d expression in vivo minimally affects NKT-enhanced antibody production but boosts B-cell memory. Int Immunol. 2011 Apr; 23(4):251-60.
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Autoimmunity and Klinefelter's syndrome: when men have two X chromosomes. J Autoimmun. 2009 Aug; 33(1):31-4.
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Presentation of arthritogenic peptide to antigen-specific T cells by fibroblast-like synoviocytes. Arthritis Rheum. 2007 May; 56(5):1497-506.
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Priming of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cell responses by dendritic cells loaded with HIV-1 proteins. J Infect Dis. 2003 Jan 15; 187(2):315-9.
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Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002 Dec; 46(12):3251-8.
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Lck activity controls CD4/CD8 T cell lineage commitment. Immunity. 2000 Mar; 12(3):313-22.