Calcitonin Gene-Related Peptide
"Calcitonin Gene-Related Peptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
| Descriptor ID |
D015740
|
| MeSH Number(s) |
D12.644.400.097 D12.776.631.650.097
|
| Concept/Terms |
Calcitonin Gene-Related Peptide- Calcitonin Gene-Related Peptide
- Calcitonin Gene Related Peptide
- Gene-Related Peptide, Calcitonin
- Peptide, Calcitonin Gene-Related
|
Below are MeSH descriptors whose meaning is more general than "Calcitonin Gene-Related Peptide".
Below are MeSH descriptors whose meaning is more specific than "Calcitonin Gene-Related Peptide".
This graph shows the total number of publications written about "Calcitonin Gene-Related Peptide" by people in this website by year, and whether "Calcitonin Gene-Related Peptide" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 2 | 0 | 2 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 3 | 4 |
| 2004 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Calcitonin Gene-Related Peptide" by people in Profiles.
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Variable CGRP family peptide signaling durations and the structural determinants thereof. Biochem Pharmacol. 2024 Jun; 224:116235.
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A Monoclonal Anti-Calcitonin Gene-Related Peptide Antibody Decreases Stress-Induced Colonic Hypersensitivity. J Pharmacol Exp Ther. 2021 11; 379(3):270-279.
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Biochemical characterization of G protein coupling to calcitonin gene-related peptide and adrenomedullin receptors using a native PAGE assay. J Biol Chem. 2020 07 10; 295(28):9736-9751.
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Structure-function analyses reveal a triple ß-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design. J Biol Chem. 2018 10 12; 293(41):15840-15854.
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Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. Mol Pharmacol. 2018 04; 93(4):355-367.
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Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Mol Cell. 2015 Jun 18; 58(6):1040-52.
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Selective CGRP and adrenomedullin peptide binding by tethered RAMP-calcitonin receptor-like receptor extracellular domain fusion proteins. Protein Sci. 2013 Dec; 22(12):1775-85.
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Effects of spinal cord stimulation with "standard clinical" and higher frequencies on peripheral blood flow in rats. Brain Res. 2010 Feb 08; 1313:53-61.
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Roles of peripheral terminals of transient receptor potential vanilloid-1 containing sensory fibers in spinal cord stimulation-induced peripheral vasodilation. Brain Res. 2007 Jul 02; 1156:80-92.
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GABAergic mechanisms of gastroprotection in the rat: role of sensory neurons, prostaglandins, and nitric oxide. Dig Dis Sci. 2004 Nov-Dec; 49(11-12):1875-81.