"Adrenomedullin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.
| Descriptor ID |
D053607
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| MeSH Number(s) |
D06.472.699.077 D12.644.548.017
|
| Concept/Terms |
PAMP(1-20)NH2- PAMP(1-20)NH2
- Proadrenomedullin N-Terminal 20 Peptide
- Proadrenomedullin N Terminal 20 Peptide
- Proadrenomedullin (1-20)
|
Below are MeSH descriptors whose meaning is more general than "Adrenomedullin".
Below are MeSH descriptors whose meaning is more specific than "Adrenomedullin".
This graph shows the total number of publications written about "Adrenomedullin" by people in this website by year, and whether "Adrenomedullin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 3 | 0 | 3 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Adrenomedullin" by people in Profiles.
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Variable CGRP family peptide signaling durations and the structural determinants thereof. Biochem Pharmacol. 2024 Jun; 224:116235.
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Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival. Peptides. 2019 02; 112:96-100.
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Structure-function analyses reveal a triple ß-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design. J Biol Chem. 2018 10 12; 293(41):15840-15854.
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Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. Mol Pharmacol. 2018 04; 93(4):355-367.
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Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium. Biol Reprod. 2017 Sep 01; 97(3):466-477.
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Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. J Biol Chem. 2016 May 27; 291(22):11657-75.
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Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Mol Cell. 2015 Jun 18; 58(6):1040-52.
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Selective CGRP and adrenomedullin peptide binding by tethered RAMP-calcitonin receptor-like receptor extracellular domain fusion proteins. Protein Sci. 2013 Dec; 22(12):1775-85.