"TRPV Cation Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subgroup of TRP cation channels named after the vanilloid receptor. They are very sensitive to TEMPERATURE; hot spicy food, and CAPSAICIN. They contain a TRP domain (a five-turn amphipathic helix with an invariant TRYPTOPHAN) and ANKYRIN repeats. Selectivity for CALCIUM over SODIUM ranges from 3 to 100 fold.
| Descriptor ID |
D050916
|
| MeSH Number(s) |
D12.776.157.530.400.901.888
|
| Concept/Terms |
TRPV Cation Channels- TRPV Cation Channels
- Cation Channels, TRPV
- Channels, TRPV Cation
- Capsaicin Receptors
- Receptors, Capsaicin
- Vanilloid Receptors
- Receptors, Vanilloid
|
Below are MeSH descriptors whose meaning is more general than "TRPV Cation Channels".
Below are MeSH descriptors whose meaning is more specific than "TRPV Cation Channels".
This graph shows the total number of publications written about "TRPV Cation Channels" by people in this website by year, and whether "TRPV Cation Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 3 | 0 | 3 |
| 2007 | 1 | 1 | 2 |
| 2010 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "TRPV Cation Channels" by people in Profiles.
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Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation. J Clin Invest. 2024 May 21; 134(13).
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TRPV1-Lineage Somatosensory Fibers Communicate with Taste Neurons in the Mouse Parabrachial Nucleus. J Neurosci. 2022 03 02; 42(9):1719-1737.
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Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension. J Lipid Res. 2021; 62:100145.
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The novel capsazepine analog, CIDD-99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1-independent induction of ER stress, mitochondrial dysfunction, and apoptosis. J Oral Pathol Med. 2019 May; 48(5):389-399.
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Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types. Bioorg Med Chem. 2019 01 01; 27(1):208-215.
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Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma. Int J Oncol. 2018 Dec; 53(6):2627-2636.
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Differences in the Control of Secondary Peristalsis in the Human Esophagus: Influence of the 5-HT4 Receptor versus the TRPV1 Receptor. PLoS One. 2016; 11(7):e0159452.
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Differential effects of intravesical resiniferatoxin on excitability of bladder spinal neurons upon colon-bladder cross-sensitization. Brain Res. 2013 Jan 23; 1491:213-24.
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Diabetic rats show reduced cardiac-somatic reflex evoked by intrapericardial capsaicin. Eur J Pharmacol. 2011 Jan 25; 651(1-3):83-8.
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A novel TRPV1 receptor antagonist JNJ-17203212 attenuates colonic hypersensitivity in rats. Methods Find Exp Clin Pharmacol. 2010 Oct; 32(8):557-64.