Protein Tyrosine Phosphatase, Non-Receptor Type 1
"Protein Tyrosine Phosphatase, Non-Receptor Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.
| Descriptor ID |
D054562
|
| MeSH Number(s) |
D08.811.277.352.650.775.300.100 D12.644.360.585.100 D12.776.476.564.100
|
| Concept/Terms |
Protein Tyrosine Phosphatase, Non-Receptor Type 1- Protein Tyrosine Phosphatase, Non-Receptor Type 1
- Protein Tyrosine Phosphatase, Non Receptor Type 1
- PTPase HA2
- Protein Tyrosine Phosphatase 1B
- PTPase 1B
- Protein-Tyrosine Phosphatase HA2
- Protein Tyrosine Phosphatase HA2
|
Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 1".
Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 1".
This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 1" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
| 2012 | 1 | 0 | 1 |
| 2013 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 1" by people in Profiles.
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Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14. Biomolecules. 2021 04 19; 11(4).
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Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival. Oncotarget. 2016 Jul 26; 7(30):46924-46942.
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Spatial and temporal aspects and the interplay of Grb14 and protein tyrosine phosphatase-1B on the insulin receptor phosphorylation. Cell Commun Signal. 2013 Dec 18; 11:96.
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Neuroprotective role of protein tyrosine phosphatase-1B in rod photoreceptor neurons. Protein Cell. 2013 Dec; 4(12):890-2.
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Protein tyrosine phosphatase 1B: a novel molecular target for retinal degenerative diseases. Adv Exp Med Biol. 2012; 723:829-34.
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Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14. Mol Cell Biol. 2011 Oct; 31(19):3975-87.
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Tea contains potent inhibitors of tyrosine phosphatase PTP1B. Biochem Biophys Res Commun. 2011 Apr 01; 407(1):98-102.
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Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene. J Biol Chem. 2010 Mar 19; 285(12):8894-904.
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Retinal insulin receptor signaling in hyperosmotic stress. Vitam Horm. 2009; 80:583-612.
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Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1033-40.