Sterol Regulatory Element Binding Protein 1
"Sterol Regulatory Element Binding Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
| Descriptor ID |
D051780
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| MeSH Number(s) |
D12.776.260.103.500.750.500 D12.776.260.108.092.750.500 D12.776.930.125.500.750.500 D12.776.930.127.092.750.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sterol Regulatory Element Binding Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Sterol Regulatory Element Binding Protein 1".
This graph shows the total number of publications written about "Sterol Regulatory Element Binding Protein 1" by people in this website by year, and whether "Sterol Regulatory Element Binding Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 2 | 3 |
| 2016 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sterol Regulatory Element Binding Protein 1" by people in Profiles.
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Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth. Nat Metab. 2022 May; 4(5):575-588.
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Liver X receptor-a activation enhances cholesterol secretion in lactating mammary epithelium. Am J Physiol Endocrinol Metab. 2019 06 01; 316(6):E1136-E1145.
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Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth. Cell Rep. 2016 Aug 09; 16(6):1527-1535.
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Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis. Clin Cancer Res. 2016 Nov 01; 22(21):5337-5348.
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Role of cystathionine beta synthase in lipid metabolism in ovarian cancer. Oncotarget. 2015 Nov 10; 6(35):37367-84.
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Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth. Cancer Cell. 2015 Nov 09; 28(5):569-581.
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Ferulic acid regulates hepatic GLUT2 gene expression in high fat and fructose-induced type-2 diabetic adult male rat. Eur J Pharmacol. 2015 Aug 15; 761:391-7.
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Moderate GLUT4 overexpression improves insulin sensitivity and fasting triglyceridemia in high-fat diet-fed transgenic mice. Diabetes. 2013 Jul; 62(7):2249-58.
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Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium. Am J Physiol Endocrinol Metab. 2010 Dec; 299(6):E918-27.
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CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J Biol Chem. 2007 May 25; 282(21):15717-29.