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PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-ß1 production.
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PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-ß1 production.
PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-ß1 production. Sci Transl Med. 2018 09 26; 10(460).
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PubMed
subject areas
Adult
Adult
Aged
Aged
Animals
Animals
Bleomycin
Bleomycin
CD4-Positive T-Lymphocytes
CD4-Positive T-Lymphocytes
Cell Proliferation
Cell Proliferation
Collagen Type I
Collagen Type I
Disease Models, Animal
Disease Models, Animal
Female
Female
Fibroblasts
Fibroblasts
Gene Expression Regulation
Gene Expression Regulation
Humans
Humans
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Interleukin-17
Interleukin-17
Male
Male
Mice
Mice
Middle Aged
Middle Aged
Programmed Cell Death 1 Receptor
Programmed Cell Death 1 Receptor
RNA, Messenger
RNA, Messenger
Sarcoidosis
Sarcoidosis
STAT3 Transcription Factor
STAT3 Transcription Factor
Th17 Cells
Th17 Cells
Transforming Growth Factor beta1
Transforming Growth Factor beta1
Up-Regulation
Up-Regulation
authors with profiles
Courtney Gray Montgomery