TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus.
TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus. Genes Immun. 2016 04; 17(3):165-70.
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Down-Regulation
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Down-Regulation
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Enhancer Elements, Genetic
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Enhancer Elements, Genetic
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HEK293 Cells
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HEK293 Cells
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Humans
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Humans
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Lupus Erythematosus, Systemic
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Lupus Erythematosus, Systemic
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Mutation
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Mutation
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NF-kappa B
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NF-kappa B
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Phenotype
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Phenotype
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Polymorphism, Single Nucleotide
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Polymorphism, Single Nucleotide
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Promoter Regions, Genetic
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Promoter Regions, Genetic
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RNA, Messenger
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RNA, Messenger
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Signal Transduction
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Signal Transduction
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Tumor Necrosis Factor alpha-Induced Protein 3
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Tumor Necrosis Factor alpha-Induced Protein 3