"Chloroquine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
| Descriptor ID |
D002738
|
| MeSH Number(s) |
D03.633.100.810.050.180
|
| Concept/Terms |
Chloroquine Sulfate- Chloroquine Sulfate
- Sulfate, Chloroquine
- Chloroquine Sulphate
- Sulphate, Chloroquine
|
Below are MeSH descriptors whose meaning is more general than "Chloroquine".
Below are MeSH descriptors whose meaning is more specific than "Chloroquine".
This graph shows the total number of publications written about "Chloroquine" by people in this website by year, and whether "Chloroquine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 1 | 3 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Chloroquine" by people in Profiles.
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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nat Med. 2019 04; 25(4):628-640.
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Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions. Mol Pharm. 2016 Mar 07; 13(3):839-51.
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Chloroquine is a zinc ionophore. PLoS One. 2014; 9(10):e109180.
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Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands. Bioorg Med Chem. 2014 Jul 01; 22(13):3239-44.
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Chloroquine-mediated cell death in metastatic pancreatic adenocarcinoma through inhibition of autophagy. JOP. 2014 Mar 10; 15(2):189-97.
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Inhibition of autophagy with chloroquine is effective in melanoma. J Surg Res. 2013 Sep; 184(1):274-81.
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Quantitation of "autophagic flux" in mature skeletal muscle. Autophagy. 2010 Oct; 6(7):929-35.
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Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol. 2009 Dec 14; 187(6):875-88.