Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype.

Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood-Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype. J Gerontol A Biol Sci Med Sci. 2018 06 14; 73(7):853-863.

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subject areas

Aging
Aging
Alzheimer Disease
Alzheimer Disease
Amyloidogenic Proteins
Amyloidogenic Proteins
Animals
Animals
Blood-Brain Barrier
Blood-Brain Barrier
Cognitive Dysfunction
Cognitive Dysfunction
Diet, High-Fat
Diet, High-Fat
Disease Models, Animal
Disease Models, Animal
Gene Expression
Gene Expression
Hippocampus
Hippocampus
Inflammation
Inflammation
Male
Male
Mice
Mice
Mice, Inbred ICR
Mice, Inbred ICR
Mice, Knockout
Mice, Knockout
Neuronal Plasticity
Neuronal Plasticity
NF-E2-Related Factor 2
NF-E2-Related Factor 2
Obesity
Obesity
Oxidative Stress
Oxidative Stress
Phenotype
Phenotype

authors with profiles

Andriy Yabluchanskiy
Anna Csiszar
Michael Hale Elliott
Stefano Tarantini
William Edmund Sonntag
Zoltan Ungvari