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Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.
AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1a stabilization.
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AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1a stabilization.
AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1a stabilization. Cancer Lett. 2017 03 01; 388:149-157.
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PubMed
subject areas
Animals
Cell Hypoxia
Electron Transport Complex I
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Indoles
Mice
Pyrimidines
authors with profiles
Michael Ihnat