"MutL Protein Homolog 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.
| Descriptor ID |
D000070957
|
| MeSH Number(s) |
D08.811.074.766.500 D08.811.277.040.025.215.500 D12.776.260.540.500
|
| Concept/Terms |
MutL Protein Homolog 1- MutL Protein Homolog 1
- MLH1 Protein
- Colon Cancer, Nonpolyposis Type 2 Protein
- MutL Homolog 1
- COCA2 Protein
|
Below are MeSH descriptors whose meaning is more general than "MutL Protein Homolog 1".
Below are MeSH descriptors whose meaning is more specific than "MutL Protein Homolog 1".
This graph shows the total number of publications written about "MutL Protein Homolog 1" by people in this website by year, and whether "MutL Protein Homolog 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "MutL Protein Homolog 1" by people in Profiles.
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Endometrial Cancer Characteristics and Risk of Recurrence. Am J Clin Pathol. 2022 Jan 06; 157(1):90-97.
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Population bias in somatic measurement of microsatellite instability status. Cancer Med. 2020 09; 9(17):6452-6460.
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BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations. Oncotarget. 2017 Jun 20; 8(25):39945-39962.
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High microsatellite instability (MSI-H) colorectal carcinoma: a brief review of predictive biomarkers in the era of personalized medicine. Fam Cancer. 2016 07; 15(3):405-12.
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DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis. J Biol Chem. 2008 Aug 01; 283(31):21394-403.
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Defective DNA mismatch repair in long-term (> or =3 years) survivors with pancreatic cancer. Pancreatology. 2005; 5(2-3):220-7; discussion 227-8.
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Loss of mismatch repair proteins in sebaceous gland tumors. J Cutan Pathol. 2003 Mar; 30(3):178-84.