"Leupeptins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.
| Descriptor ID |
D007976
|
| MeSH Number(s) |
D12.644.456.580
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Leupeptins".
Below are MeSH descriptors whose meaning is more specific than "Leupeptins".
This graph shows the total number of publications written about "Leupeptins" by people in this website by year, and whether "Leupeptins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Leupeptins" by people in Profiles.
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Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes. Biochim Biophys Acta Mol Basis Dis. 2017 11; 1863(11):2924-2933.
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Identification of proteins associated with Aha1 in HeLa cells by quantitative proteomics. Biochim Biophys Acta. 2015 May; 1854(5):365-80.
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Tyrosine nitration of PA700 links proteasome activation to endothelial dysfunction in mouse models with cardiovascular risk factors. PLoS One. 2012; 7(1):e29649.
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Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons. Mol Cancer Ther. 2006 Jan; 5(1):29-38.
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Inhibition of constitutively activated nuclear factor-kappaB radiosensitizes human melanoma cells. Mol Cancer Ther. 2004 Aug; 3(8):985-92.
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The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev. 2003 Jan 01; 17(1):101-14.
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A proteasome inhibitor, an antioxidant, or a salicylate, but not a glucocorticoid, blocks constitutive and cytokine-inducible expression of P-selectin in human endothelial cells. Blood. 1998 Mar 01; 91(5):1625-32.