| Item Type | Name |
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Concept
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Fingolimod Hydrochloride
|
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Concept
|
Analysis of Variance
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Concept
|
Adrenocorticotropic Hormone
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Concept
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Animals
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Concept
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Aging
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Concept
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Mechanistic Target of Rapamycin Complex 1
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Concept
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Calcium
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Concept
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Acetyltransferases
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Concept
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Amino Acid Sequence
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Concept
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Actins
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Concept
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Adenocarcinoma
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Concept
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Carcinoma in Situ
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Concept
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trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
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Concept
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Blood Glucose
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Concept
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Body Weight
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Concept
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Cartilage, Articular
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Concept
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Brain Mapping
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Concept
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Cattle
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Concept
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Chromatography, Gas
|
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Concept
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Chromatography, Thin Layer
|
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Concept
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Corticosterone
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Concept
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Circadian Rhythm
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Concept
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Detergents
|
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Concept
|
Hexokinase
|
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Concept
|
Cyclic GMP
|
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Concept
|
Guanylate Cyclase
|
|
Concept
|
Hippocampus
|
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Concept
|
Histidine
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Concept
|
Electrophoresis, Polyacrylamide Gel
|
|
Concept
|
Electroretinography
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Concept
|
Humans
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Concept
|
Gene Expression Regulation
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Concept
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Genes, Dominant
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Concept
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Genotype
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Concept
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Light
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Concept
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Linseed Oil
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Concept
|
Lipoproteins
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Concept
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Macula Lutea
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Concept
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Macular Degeneration
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Concept
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Injections, Intraperitoneal
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Concept
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Neuronal Plasticity
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Concept
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Mutation
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Concept
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Nerve Fibers, Myelinated
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Concept
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Synaptic Transmission
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Concept
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Mice, Inbred BALB C
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Concept
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Mice, Inbred C57BL
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Concept
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Mice, Mutant Strains
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Concept
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Mice, Transgenic
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Concept
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Actin Cytoskeleton
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Concept
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Microsomes
|
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Concept
|
Phosphatidylcholines
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|
Concept
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Phosphatidylethanolamines
|
|
Concept
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Phosphatidylserines
|
|
Concept
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Phosphoric Diester Hydrolases
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Concept
|
Phospholipids
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|
Concept
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Mosaicism
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Concept
|
Photoreceptor Cells
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Concept
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Pancreatic Neoplasms
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Concept
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Safflower Oil
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Concept
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Retina
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Concept
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Retinitis Pigmentosa
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Concept
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Seizures
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Concept
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Rhodopsin
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Concept
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RNA, Messenger
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|
Concept
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Rod Cell Outer Segment
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|
Concept
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Synovial Membrane
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Concept
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Radiation Injuries, Experimental
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|
Concept
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Testis
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|
Concept
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Receptor, Insulin
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Concept
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Fatty Acids, Omega-3
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Concept
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Down-Regulation
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Concept
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Blotting, Western
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Concept
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Staining and Labeling
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Concept
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Electrophoresis, Gel, Two-Dimensional
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|
Concept
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Lipid Peroxidation
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|
Concept
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Sterols
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|
Concept
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Transducin
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|
Concept
|
Rats, Sprague-Dawley
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|
Concept
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Rats, Wistar
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|
Concept
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Sucrose
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|
Concept
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Rod Opsins
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|
Concept
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Gene Deletion
|
|
Concept
|
Reactive Oxygen Species
|
|
Concept
|
Sequence Deletion
|
|
Concept
|
Proliferating Cell Nuclear Antigen
|
|
Concept
|
Vision, Ocular
|
|
Concept
|
Conserved Sequence
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|
Concept
|
Disease Progression
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|
Concept
|
Mutagenesis, Site-Directed
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|
Concept
|
Neuroprotective Agents
|
|
Concept
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Transgenes
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|
Concept
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Smith-Lemli-Opitz Syndrome
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|
Concept
|
Bruch Membrane
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Catalytic Domain
|
|
Concept
|
In Situ Nick-End Labeling
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|
Concept
|
Arachidonic Acid
|
|
Concept
|
Peroxisomes
|
|
Concept
|
Rats, Long-Evans
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|
Concept
|
Spinocerebellar Ataxias
|
|
Concept
|
Glycerophospholipids
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|
Concept
|
Photoreceptor Cells, Vertebrate
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|
Concept
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Animals, Genetically Modified
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|
Concept
|
Mice, Knockout
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|
Concept
|
Caenorhabditis elegans Proteins
|
|
Concept
|
cis-trans-Isomerases
|
|
Concept
|
Phosphatidylinositol 3-Kinases
|
|
Concept
|
Cyclin D1
|
|
Concept
|
Amino Acid Substitution
|
|
Concept
|
Pro-Opiomelanocortin
|
|
Concept
|
Fatty Acids, Omega-6
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Propylene Glycols
|
|
Concept
|
Protein Processing, Post-Translational
|
|
Concept
|
Fatty Acid Desaturases
|
|
Concept
|
Scavenger Receptors, Class B
|
|
Concept
|
Mice
|
|
Concept
|
Rats
|
|
Concept
|
Guanylate Cyclase-Activating Proteins
|
|
Concept
|
G-Protein-Coupled Receptor Kinase 1
|
|
Concept
|
Sperm Count
|
|
Concept
|
Sperm Head
|
|
Concept
|
Sperm Motility
|
|
Concept
|
Spermatogenesis
|
|
Concept
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Spermatozoa
|
|
Concept
|
Sphingolipids
|
|
Concept
|
Sphingomyelins
|
|
Concept
|
Sphingosine
|
|
Concept
|
Triglycerides
|
|
Concept
|
Semen Analysis
|
|
Concept
|
Retinal Pigment Epithelium
|
|
Concept
|
Night Vision
|
|
Concept
|
5-Lipoxygenase-Activating Proteins
|
|
Concept
|
Cysteine Proteinase Inhibitors
|
|
Concept
|
RNA, Small Interfering
|
|
Concept
|
Cytokines
|
|
Concept
|
Papio anubis
|
|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Cell Proliferation
|
|
Concept
|
Octoxynol
|
|
Concept
|
Tomography, Optical Coherence
|
|
Concept
|
Retinal Rod Photoreceptor Cells
|
|
Concept
|
Retinal Cone Photoreceptor Cells
|
|
Concept
|
Tandem Mass Spectrometry
|
|
Concept
|
Proto-Oncogene Proteins c-bcl-2
|
|
Concept
|
Integrases
|
|
Concept
|
Hep G2 Cells
|
|
Concept
|
Linoleoyl-CoA Desaturase
|
|
Concept
|
Dietary Supplements
|
|
Concept
|
Gene Expression Profiling
|
|
Concept
|
Cyclic Nucleotide Phosphodiesterases, Type 6
|
|
Concept
|
Myocytes, Cardiac
|
|
Concept
|
Microscopy, Electron, Transmission
|
|
Concept
|
Rats, Transgenic
|
|
Concept
|
Gene Knockdown Techniques
|
|
Concept
|
Erythrokeratodermia Variabilis
|
|
Concept
|
Real-Time Polymerase Chain Reaction
|
|
Concept
|
Arachidonate 5-Lipoxygenase
|
|
Concept
|
Arthritis, Experimental
|
|
Concept
|
Ataxia
|
|
Concept
|
Cell Survival
|
|
Concept
|
Centrifugation, Density Gradient
|
|
Concept
|
Ceramides
|
|
Concept
|
Cholestadienes
|
|
Concept
|
Cholesterol
|
|
Concept
|
Sterol Esterase
|
|
Concept
|
Dietary Fats
|
|
Concept
|
Dietary Fats, Unsaturated
|
|
Concept
|
Disease Models, Animal
|
|
Concept
|
Disease Susceptibility
|
|
Concept
|
Docosahexaenoic Acids
|
|
Concept
|
Immunohistochemistry
|
|
Concept
|
Immunosuppressive Agents
|
|
Concept
|
Gas Chromatography-Mass Spectrometry
|
|
Concept
|
Membrane Lipids
|
|
Concept
|
Organ Culture Techniques
|
|
Concept
|
Osteoarthritis
|
|
Academic Article
|
ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3.
|
|
Academic Article
|
Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity.
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|
Academic Article
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In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.
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|
Academic Article
|
Differential composition of DHA and very-long-chain PUFAs in rod and cone photoreceptors.
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|
Academic Article
|
Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint.
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|
Academic Article
|
Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies.
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|
Academic Article
|
Deciphering mutant ELOVL4 activity in autosomal-dominant Stargardt macular dystrophy.
|
|
Academic Article
|
Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids.
|
|
Academic Article
|
Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice.
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|
Academic Article
|
Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency.
|
|
Academic Article
|
Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse.
|
|
Academic Article
|
The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration.
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|
Academic Article
|
Decreased very long chain polyunsaturated fatty acids in sperm correlates with sperm quantity and quality.
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|
Academic Article
|
Detailed characterization of the lipid composition of detergent-resistant membranes from photoreceptor rod outer segment membranes.
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|
Academic Article
|
Effects of low AIPL1 expression on phototransduction in rods.
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|
Academic Article
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High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degeneration.
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|
Academic Article
|
Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice.
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|
Academic Article
|
Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina.
|
|
Academic Article
|
Pyruvate kinase M2 regulates photoreceptor structure, function, and viability.
|
|
Academic Article
|
Phosphoinositide Lipids in Ocular Tissues.
|
|
Academic Article
|
Bright cyclic rearing protects albino mouse retina against acute light-induced apoptosis.
|
|
Academic Article
|
Lipid differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations.
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|
Academic Article
|
Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors.
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|
Academic Article
|
Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors.
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|
Academic Article
|
Effect of reduced retinal VLC-PUFA on rod and cone photoreceptors.
|
|
Academic Article
|
Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina.
|
|
Academic Article
|
Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation.
|
|
Academic Article
|
Correlation between tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration.
|
|
Academic Article
|
Retinal sphingolipids and their very-long-chain fatty acid-containing species.
|
|
Academic Article
|
Ceramide signaling in retinal degeneration.
|
|
Academic Article
|
Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration.
|
|
Academic Article
|
Examination of VLC-PUFA-deficient photoreceptor terminals.
|
|
Academic Article
|
Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4.
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|
Academic Article
|
HK2 Mediated Glycolytic Metabolism in Mouse Photoreceptors Is Not Required to Cause Late Stage Age-Related Macular Degeneration-Like Pathologies.
|
|
Academic Article
|
W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34.
|
|
Academic Article
|
Obesity promotes lipid accumulation in mouse cartilage-A potential role of acetyl-CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis.
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Academic Article
|
Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.
|
|
Academic Article
|
Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation.
|
|
Academic Article
|
Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration.
|
|
Academic Article
|
Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver.
|
|
Academic Article
|
Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis.
|
|
Academic Article
|
ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis.
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|
Academic Article
|
Sperm very long-chain polyunsaturated fatty acids: relation to semen parameters and live birth outcome in a multicenter trial.
|
|
Academic Article
|
Response of the Glutathione (GSH) Antioxidant Defense System to Oxidative Injury in Necrotizing Enterocolitis.
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Academic Article
|
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report.
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Academic Article
|
Novel Approaches for Elongation of Fish Oils into Very-Long-Chain Polyunsaturated Fatty Acids and Their Enzymatic Interesterification into Glycerolipids.
|