| Item Type | Name |
|
Concept
|
Carrier Proteins
|
|
Concept
|
Heat-Shock Proteins
|
|
Concept
|
Nuclear Proteins
|
|
Concept
|
Neoplasm Proteins
|
|
Concept
|
Nerve Tissue Proteins
|
|
Concept
|
Repressor Proteins
|
|
Concept
|
Recombinant Fusion Proteins
|
|
Concept
|
Recombinant Proteins
|
|
Concept
|
Retroviridae Proteins, Oncogenic
|
|
Concept
|
Viral Proteins
|
|
Concept
|
Cell Cycle Proteins
|
|
Concept
|
HSP70 Heat-Shock Proteins
|
|
Concept
|
HSP90 Heat-Shock Proteins
|
|
Concept
|
Homeodomain Proteins
|
|
Concept
|
GTP-Binding Proteins
|
|
Concept
|
Avian Proteins
|
|
Concept
|
Saccharomyces cerevisiae Proteins
|
|
Concept
|
Drosophila Proteins
|
|
Concept
|
Zebrafish Proteins
|
|
Concept
|
Proteins
|
|
Concept
|
Tumor Suppressor Proteins
|
|
Concept
|
Proto-Oncogene Proteins
|
|
Concept
|
Cullin Proteins
|
|
Concept
|
Proto-Oncogene Proteins c-akt
|
|
Concept
|
Proto-Oncogene Proteins c-fyn
|
|
Concept
|
Proto-Oncogene Proteins c-hck
|
|
Concept
|
HSC70 Heat-Shock Proteins
|
|
Concept
|
Tacrolimus Binding Proteins
|
|
Concept
|
DNA-Binding Proteins
|
|
Concept
|
Fungal Proteins
|
|
Academic Article
|
Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates.
|
|
Academic Article
|
Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90.
|
|
Academic Article
|
Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase.
|
|
Academic Article
|
Differential inhibition of Hsc70 activities by two Hsc70-binding peptides.
|
|
Academic Article
|
High affinity binding of Hsp90 is triggered by multiple discrete segments of its kinase clients.
|
|
Academic Article
|
Functional dissection of cdc37: characterization of domain structure and amino acid residues critical for protein kinase binding.
|
|
Academic Article
|
Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions.
|
|
Academic Article
|
Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.
|
|
Academic Article
|
Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase.
|
|
Academic Article
|
Assays for identification of Hsp90 inhibitors and biochemical methods for discriminating their mechanism of action.
|
|
Academic Article
|
Gambogic acid, a natural product inhibitor of Hsp90.
|
|
Academic Article
|
Elucidation of the Hsp90 C-terminal inhibitor binding site.
|
|
Academic Article
|
Approaches for defining the Hsp90-dependent proteome.
|
|
Academic Article
|
Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.
|
|
Academic Article
|
Structure-guided design of an Hsp90ß N-terminal isoform-selective inhibitor.
|
|
Academic Article
|
Interactions of the heme-regulated eIF-2 alpha kinase with heat shock proteins in rabbit reticulocyte lysates.
|
|
Academic Article
|
The relationship between protein synthesis and heat shock proteins levels in rabbit reticulocyte lysates.
|
|
Academic Article
|
Evidence for the association of the heme-regulated eIF-2 alpha kinase with the 90-kDa heat shock protein in rabbit reticulocyte lysate in situ.
|
|
Academic Article
|
Effect of interferon on protein translation during growth stages of 3T3 cells.
|
|
Academic Article
|
Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B.
|
|
Academic Article
|
Changes in the expression of the heme-regulated eIF-2 alpha kinase and heat shock proteins in rabbit reticulocytes maturing during recovery from anemia.
|
|
Academic Article
|
Dual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the alpha subunit of eukaryotic translation initiation factor 2.
|
|
Academic Article
|
The heme-regulated eukaryotic initiation factor 2alpha kinase. A potential regulatory target for control of protein synthesis by diffusible gases.
|
|
Academic Article
|
Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase.
|
|
Academic Article
|
Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase.
|
|
Academic Article
|
High-throughput assay for the identification of Hsp90 inhibitors based on Hsp90-dependent refolding of firefly luciferase.
|
|
Academic Article
|
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.
|
|
Academic Article
|
The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.
|
|
Academic Article
|
Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.
|
|
Academic Article
|
Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex.
|
|
Academic Article
|
High Throughput Screening for Natural Host Defense Peptide-Inducing Compounds as Novel Alternatives to Antibiotics.
|
|
Academic Article
|
Effect of phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 on the function of reversing factor in the initiation of protein synthesis.
|
|
Academic Article
|
Distribution of reversing factor in reticulocyte lysates during active protein synthesis and on inhibition by heme deprivation or double-stranded RNA.
|
|
Academic Article
|
The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2.
|
|
Academic Article
|
Association of Hsp90 with cellular Src-family kinases in a cell-free system correlates with altered kinase structure and function.
|
|
Academic Article
|
Denatured proteins inhibit translation in hemin-supplemented rabbit reticulocyte lysate by inducing the activation of the heme-regulated eIF-2 alpha kinase.
|
|
Academic Article
|
The outcome of poliovirus infections in K562 cells is cytolytic rather than persistent after hemin-induced differentiation.
|
|
Academic Article
|
Effect of geldanamycin on the kinetics of chaperone-mediated renaturation of firefly luciferase in rabbit reticulocyte lysate.
|
|
Academic Article
|
Hsp90-mediated folding of the lymphoid cell kinase p56lck.
|
|
Academic Article
|
Modular folding and evidence for phosphorylation-induced stabilization of an hsp90-dependent kinase.
|
|
Academic Article
|
Luciferase renaturation assays of chaperones and chaperone antagonists.
|
|
Academic Article
|
The N-terminal region of the heme-regulated eIF2alpha kinase is an autonomous heme binding domain.
|
|
Academic Article
|
Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion.
|
|
Academic Article
|
Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases.
|
|
Academic Article
|
The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart.
|
|
Academic Article
|
Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.
|
|
Academic Article
|
Evidence for chaperone heterocomplexes containing both Hsp90 and VCP.
|
|
Academic Article
|
Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation.
|
|
Academic Article
|
Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37.
|
|
Academic Article
|
Cdk2: a genuine protein kinase client of Hsp90 and Cdc37.
|
|
Academic Article
|
Derrubone, an inhibitor of the Hsp90 protein folding machinery.
|
|
Academic Article
|
Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.
|
|
Academic Article
|
Correlation between the distribution of the reversing factor and eukaryotic initiation factor 2 in heme-deficient or double-stranded RNA-inhibited reticulocyte lysates.
|
|
Academic Article
|
Fate of reversing factor during restoration of protein synthesis by hemin or GTP in heme-deficient reticulocyte lysates.
|
|
Academic Article
|
Identification and initial SAR of silybin: an Hsp90 inhibitor.
|
|
Academic Article
|
Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.
|
|
Academic Article
|
Phosphorothioated binary complex of eukaryotic initiation factor eIF-2 and GDP inhibits protein synthesis in hemin-supplemented reticulocyte lysates.
|
|
Academic Article
|
A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine.
|
|
Academic Article
|
Proteomic Profiling of Hsp90 Inhibitors.
|
|
Academic Article
|
ATP-dependent chaperoning activity of reticulocyte lysate.
|
|
Academic Article
|
Hsp90 is obligatory for the heme-regulated eIF-2alpha kinase to acquire and maintain an activable conformation.
|
|
Academic Article
|
Evidence that Hsc70 negatively modulates the activation of the heme-regulated eIF-2alpha kinase in rabbit reticulocyte lysate.
|
|
Academic Article
|
p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules.
|
|
Academic Article
|
p50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.
|
|
Academic Article
|
Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation.
|
|
Academic Article
|
Direct interaction of the cell division cycle 37 homolog inhibits endothelial nitric oxide synthase activity.
|
|
Academic Article
|
Direct ribosomal binding by a cellular inhibitor of translation.
|
|
Academic Article
|
Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells.
|
|
Academic Article
|
KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.
|
|
Academic Article
|
Identification of proteins associated with Aha1 in HeLa cells by quantitative proteomics.
|
|
Academic Article
|
Inhibition of rabbit reticulocyte lysate protein synthesis by heavy metal ions involves the phosphorylation of the alpha-subunit of the eukaryotic initiation factor 2.
|
|
Academic Article
|
The 60 S ribosomal subunit as a carrier of eukaryotic initiation factor 2 and the site of reversing factor activity during protein synthesis.
|
|
Academic Article
|
Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.
|
|
Academic Article
|
The role of the 90-kDa heat-shock protein and its associated cohorts in stabilizing the heme-regulated eIF-2alpha kinase in reticulocyte lysates during heat stress.
|
|
Grant
|
Identification of Natural Product Inhibitors of Hsp90 as Chemotherapeutic Agents
|
|
Grant
|
HEAVY METAL IONS--EUKARYOTIC PROTEIN SYNTHESIS
|
|
Grant
|
Structure/Function Studies of Anti-cancer Hsp90 Inhibitors that Target the C-terminal Domain
|
|
Grant
|
LCK TYROSINE KINASE/HEAT SHOCK PROTEIN INTERACTION
|
|
Academic Article
|
Selective Inhibition of the Hsp90a Isoform.
|
|
Academic Article
|
Crystal structure of the middle and C-terminal domains of Hsp90a labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target.
|