"Mice, Knockout" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Descriptor ID |
D018345
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MeSH Number(s) |
B01.050.050.136.500.500 B01.050.150.900.649.313.992.635.505.500.550.455 B01.050.150.900.649.313.992.635.505.500.800.500
|
Concept/Terms |
Mice, Knockout- Mice, Knockout
- Mice, Knock-out
- Knock-out Mice
- Mice, Knock out
- Mouse, Knockout
- Knockout Mouse
- Knockout Mice
|
Below are MeSH descriptors whose meaning is more general than "Mice, Knockout".
Below are MeSH descriptors whose meaning is more specific than "Mice, Knockout".
This graph shows the total number of publications written about "Mice, Knockout" by people in this website by year, and whether "Mice, Knockout" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 0 | 1 | 1 |
1998 | 0 | 2 | 2 |
1999 | 0 | 2 | 2 |
2000 | 0 | 4 | 4 |
2001 | 0 | 4 | 4 |
2002 | 0 | 8 | 8 |
2003 | 0 | 4 | 4 |
2004 | 0 | 17 | 17 |
2005 | 1 | 14 | 15 |
2006 | 1 | 20 | 21 |
2007 | 0 | 19 | 19 |
2008 | 0 | 29 | 29 |
2009 | 0 | 29 | 29 |
2010 | 0 | 28 | 28 |
2011 | 0 | 29 | 29 |
2012 | 0 | 37 | 37 |
2013 | 0 | 27 | 27 |
2014 | 0 | 43 | 43 |
2015 | 0 | 28 | 28 |
2016 | 0 | 37 | 37 |
2017 | 0 | 33 | 33 |
2018 | 0 | 33 | 33 |
2019 | 0 | 25 | 25 |
2020 | 0 | 22 | 22 |
2021 | 0 | 17 | 17 |
2022 | 0 | 4 | 4 |
2023 | 0 | 6 | 6 |
2024 | 2 | 8 | 10 |
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Below are the most recent publications written about "Mice, Knockout" by people in Profiles.
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Age-related retinal degeneration resulting from the deletion of Shp2 tyrosine phosphatase in photoreceptor neurons. Cell Death Dis. 2024 Aug 08; 15(8):577.
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Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1-/- mice. Biol Open. 2024 Jul 15; 13(7).
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Endothelial Chromatin-Remodeling Enzymes Regulate the Production of Critical ECM Components During Murine Lung Development. Arterioscler Thromb Vasc Biol. 2024 Aug; 44(8):1784-1798.
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The Role of CCL Chemokines in Experimental Staphylococcus aureus Endophthalmitis. Invest Ophthalmol Vis Sci. 2024 Jun 03; 65(6):12.
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Deleting Mitochondrial Superoxide Dismutase 2 in Salivary Gland Ductal Epithelial Cells Recapitulates Non-Sj?gren's Sicca Syndrome. Int J Mol Sci. 2024 May 30; 25(11).
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Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury. Cell Rep. 2024 Jun 25; 43(6):114253.
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Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy. Cell Metab. 2024 Jul 02; 36(7):1521-1533.e5.
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Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance. Proc Natl Acad Sci U S A. 2024 Apr 23; 121(17):e2320934121.
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Deletion of hepatocyte cysteine dioxygenase type 1, a bile acid repressed gene, enhances glutathione synthesis and ameliorates acetaminophen hepatotoxicity. Biochem Pharmacol. 2024 Apr; 222:116103.
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Reduced estrogen signaling contributes to bone loss and cardiac dysfunction in interleukin-10 knockout mice. Physiol Rep. 2024 Jan; 12(1):e15914.