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Karen Rae Jonscher

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentHarold Hamm Diabetes Ctr
AddressBRC 362A
975 NE 10th St
Oklahoma City OK 73104
Phone405/271-8001 ext 35506
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    Collapse Research 
    Collapse research activities and funding
    R01DK121951     (FRIEDMAN, JACOB E)Jul 1, 2020 - Jun 30, 2024
    Role of the Macrophage in Developmentally Programmed NAFLD
    Role: Co-Principal Investigator

    K25DK098615     (JONSCHER, KAREN R)Apr 1, 2013 - Jan 31, 2019
    Role of SIRT3 in fetal programming and kidney dysfunction
    Role: Principal Investigator

    F32AI010015     (JONSCHER, KAREN R)May 13, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sugino KY, Mandala A, Janssen RC, Gurung S, Trammell M, Day MW, Brush RS, Papin JF, Dyer DW, Agbaga MP, Friedman JE, Castillo-Castrejon M, Jonscher KR, Myers DA. Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver. Front Clin Diabetes Healthc. 2022; 3. PMID: 36935840; PMCID: PMC10012127.
      Citations: 1     
    2. Zhang L, Jonscher KR, Zhang Z, Xiong Y, Mueller RS, Friedman JE, Pan C. Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes. Nat Commun. 2022 06 21; 13(1):3551. PMID: 35729161.
      Citations: 2     Fields:    Translation:Humans
    3. Mandala A, Dobrinskikh E, Janssen RC, Fiehn O, D'Alessandro A, Friedman JE, Jonscher KR. Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD. Int J Mol Sci. 2022 May 27; 23(11). PMID: 35682720.
      Citations: 3     Fields:    Translation:HumansAnimals
    4. Jonscher KR, Chowanadisai W, Rucker RB. Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention. Biomolecules. 2021 09 30; 11(10). PMID: 34680074.
      Citations: 6     Fields:    Translation:HumansAnimals
    5. Jonscher KR, Abrams J, Friedman JE. Maternal Diet Alters Trained Immunity in the Pathogenesis of Pediatric NAFLD. J Cell Immunol. 2020; 2(6):315-325. PMID: 33426540.
      Citations: 2     
    6. Jonscher KR, Bruce KD. Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions. Adv Exp Med Biol. 2019; 1134:33-58. PMID: 30919331.
      Citations: 1     Fields:    Translation:Humans
    7. Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR. Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. Hepatol Commun. 2018 03; 2(3):313-328. PMID: 29507905.
      Citations: 22     Fields:    
    8. Bruce KD, Jonscher KR. Assessment of Fatty Liver in Models of Disease Programming. Methods Mol Biol. 2018; 1735:251-266. PMID: 29380318.
      Citations: 1     Fields:    Translation:AnimalsPHPublic Health
    9. Blaber EA, Pecaut MJ, Jonscher KR. Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver. Int J Mol Sci. 2017 Sep 27; 18(10). PMID: 28953266.
      Citations: 23     Fields:    Translation:AnimalsCells
    10. Pecaut MJ, Mao XW, Bellinger DL, Jonscher KR, Stodieck LS, Ferguson VL, Bateman TA, Mohney RP, Gridley DS. Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism? PLoS One. 2017; 12(5):e0174174. PMID: 28542224.
      Citations: 29     Fields:    Translation:AnimalsCells
    11. Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma EO, Fiehn O, Friedman JE. Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice. FASEB J. 2017 04; 31(4):1434-1448. PMID: 28007783.
      Citations: 25     Fields:    Translation:Animals
    12. Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol. 2017 02; 14(2):81-96. PMID: 27780972.
      Citations: 81     Fields:    Translation:HumansCells
    13. Crisp CD, Hastings-Tolsma M, Jonscher KR. Mindfulness-Based Stress Reduction for Military Women With Chronic Pelvic Pain: A Feasibility Study. Mil Med. 2016 09; 181(9):982-9. PMID: 27612341.
      Citations: 4     Fields:    Translation:Humans
    14. Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One. 2016; 11(5):e0155282. PMID: 27145222.
      Citations: 3     Fields:    
    15. Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One. 2016; 11(4):e0152877. PMID: 27097220.
      Citations: 34     Fields:    Translation:AnimalsCells
    16. Renner B, Tong HH, Laskowski J, Jonscher K, Goetz L, Woolaver R, Hannan J, Li YX, Hourcade D, Pickering MC, Holers VM, Thurman JM. Annexin A2 Enhances Complement Activation by Inhibiting Factor H. J Immunol. 2016 Feb 01; 196(3):1355-65. PMID: 26729803.
      Citations: 10     Fields:    Translation:Animals
    17. Jonscher KR, Osypuk AA, van Bokhoven A, Lucia MS. Evaluation of urinary protein precipitation protocols for the multidisciplinary approach to the study of chronic pelvic pain research network. J Biomol Tech. 2014 Dec; 25(4):118-26. PMID: 25365794.
      Citations: 2     Fields:    Translation:HumansCells
    18. Fæste CK, Jonscher KR, Dooper MM, Egge-Jacobsen W, Moen A, Daschner A, Egaas E, Christians U. Characterisation of potential novel allergens in the fish parasite Anisakis simplex. EuPA Open Proteom. 2014 Sep; 4:140-155. PMID: 27110489.
      Citations: 19     
    19. Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüß C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y, Zou C. Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012. Mol Cell Proteomics. 2013 Oct; 12(10):2935-51. PMID: 23764502.
      Citations: 48     Fields:    Translation:HumansCells
    20. Kendrick AA, Choudhury M, Rahman SM, McCurdy CE, Friederich M, Van Hove JL, Watson PA, Birdsey N, Bao J, Gius D, Sack MN, Jing E, Kahn CR, Friedman JE, Jonscher KR. Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochem J. 2011 Feb 01; 433(3):505-14. PMID: 21044047.
      Citations: 181     Fields:    Translation:AnimalsCells
    21. Choudhury M, Jonscher KR, Friedman JE. Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat. Aging (Albany NY). 2011 Feb; 3(2):175-8. PMID: 21386135.
      Citations: 40     Fields:    Translation:AnimalsCells
    22. Faeste CK, Jonscher KR, Sit L, Klawitter J, Løvberg KE, Moen LH. Differentiating cross-reacting allergens in the immunological analysis of celery (Apium graveolens) by mass spectrometry. J AOAC Int. 2010 Mar-Apr; 93(2):451-61. PMID: 20480890.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    23. Faeste CK, Christians U, Egaas E, Jonscher KR. Characterization of potential allergens in fenugreek (Trigonella foenum-graecum) using patient sera and MS-based proteomic analysis. J Proteomics. 2010 May 07; 73(7):1321-33. PMID: 20219717.
      Citations: 6     Fields:    Translation:HumansAnimals
    24. Klawitter J, Klawitter J, Kushner E, Jonscher K, Bendrick-Peart J, Leibfritz D, Christians U, Schmitz V. Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study. J Proteome Res. 2010 Feb 05; 9(2):865-75. PMID: 19994912.
      Citations: 16     Fields:    Translation:Animals
    25. Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol. 2008 Aug; 28(16):5014-26. PMID: 18559423.
      Citations: 196     Fields:    Translation:AnimalsCells
    26. Klein LL, Jonscher KR, Heerwagen MJ, Gibbs RS, McManaman JL. Shotgun proteomic analysis of vaginal fluid from women in late pregnancy. Reprod Sci. 2008 Apr; 15(3):263-73. PMID: 18421021.
      Citations: 19     Fields:    Translation:Humans
    27. Laudi S, Steudel W, Jonscher K, Schöning W, Schniedewind B, Kaisers U, Christians U, Trump S. Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension. Proteomics. 2007 Jul; 7(14):2469-78. PMID: 17623304.
      Citations: 14     Fields:    Translation:AnimalsCells
    28. Lambert C, Li J, Jonscher K, Yang TC, Reigan P, Quintana M, Harvey J, Freed BM. Acrolein inhibits cytokine gene expression by alkylating cysteine and arginine residues in the NF-kappaB1 DNA binding domain. J Biol Chem. 2007 Jul 06; 282(27):19666-75. PMID: 17491020.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    29. Jonscher KR. To trap or transmit, that is the question... Anal Chem. 2007 May 01; 79(9):3235. PMID: 17523224.
      Citations:    Fields:    Translation:Cells
    30. Armstrong M, Jonscher K, Reisdorph NA. Analysis of 25 underivatized amino acids in human plasma using ion-pairing reversed-phase liquid chromatography/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2007; 21(16):2717-26. PMID: 17659659.
      Citations: 23     Fields:    Translation:Humans
    31. Jonscher KR. Decoding the chromosome core with top-down MS. Anal Chem. 2006 Jul 01; 78(13):4244. PMID: 16856248.
      Citations:    Fields:    Translation:HumansCells
    32. Resing KA, Meyer-Arendt K, Mendoza AM, Aveline-Wolf LD, Jonscher KR, Pierce KG, Old WM, Cheung HT, Russell S, Wattawa JL, Goehle GR, Knight RD, Ahn NG. Improving reproducibility and sensitivity in identifying human proteins by shotgun proteomics. Anal Chem. 2004 Jul 01; 76(13):3556-68. PMID: 15228325.
      Citations: 70     Fields:    Translation:HumansCells
    33. Bernard KR, Jonscher KR, Resing KA, Ahn NG. Methods in functional proteomics: two-dimensional polyacrylamide gel electrophoresis with immobilized pH gradients, in-gel digestion and identification of proteins by mass spectrometry. Methods Mol Biol. 2004; 250:263-82. PMID: 14755094.
      Citations: 3     Fields:    Translation:HumansCells
    34. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Mol Cell. 2000 Dec; 6(6):1343-54. PMID: 11163208.
      Citations: 55     Fields:    Translation:HumansCells
    35. Jonscher KR, Yates JR. Matrix-assisted laser desorption ionization/quadrupole ion trap mass spectrometry of peptides. Application to the localization of phosphorylation sites on the P protein from Sendai virus. J Biol Chem. 1997 Jan 17; 272(3):1735-41. PMID: 8999854.
      Citations: 5     Fields:    Translation:Cells
    36. Jonscher KR, Yates JR. The quadrupole ion trap mass spectrometer--a small solution to a big challenge. Anal Biochem. 1997 Jan 01; 244(1):1-15. PMID: 9025900.
      Citations: 27     Fields:    
    37. Jonscher KR, Yates JR. Mixture analysis using a quadrupole mass filter/quadrupole ion trap mass spectrometer. Anal Chem. 1996 Feb 15; 68(4):659-67. PMID: 8999740.
      Citations: 1     Fields:    Translation:HumansCells
    38. Jonscher K, Currie G, McCormack AL, Yates JR. Matrix-assisted laser desorption of peptides and proteins on a quadrupole ion trap mass spectrometer. Rapid Commun Mass Spectrom. 1993 Jan; 7(1):20-6. PMID: 8428025.
      Citations: 3     Fields:    Translation:HumansAnimals
    39. JONSCHER K. [Convulsions in infancy]. Pediatr Pol. 1955 Apr; 30(4):353-60. PMID: 13266400.
      Citations:    Fields:    Translation:Humans
    40. JONSCHER K, RAFINSKI T, SZCZEPSKI O, BIEDRZYCKA B, TASZYCKA K. [Therapy of paralysis in poliomyelitis with rabies vaccine]. Pediatr Pol. 1954 Nov; 29(11):1089-96. PMID: 14356740.
      Citations:    Fields:    Translation:HumansPHPublic Health
    41. JONSCHER K. [Absence of appetite in children]. Pediatr Pol. 1953 Oct; 28(10):1027-33. PMID: 13133512.
      Citations:    Fields:    Translation:Humans
    42. JONSCHER K, FOJUDZKI E, KOSZUTSKI A, SZCZEPSKI O. [Three cases of dermatomycosis cured with aureomycin]. Pediatr Pol. 1953 Apr; 28(4):422-3. PMID: 13088149.
      Citations:    Fields:    
    43. JONSCHER K. [Peculiarities of rheumatic infection in children and its therapy]. Pediatr Pol. 1953 Mar; 28(3):233-42. PMID: 13073274.
      Citations:    Fields:    
    44. JONSCHER K, SZCZEPSKI O, TASZYCKA K. [Clinical aspects of manifestations of poliomyelitis during the last epidemic and their significance in early diagnosis]. Pediatr Pol. 1952 Jul; 27(7):769-84. PMID: 14948319.
      Citations:    Fields:    Translation:PHPublic Health
    45. JONSCHER K, FOJUDZKI E, NOWAK S, SZCZEPSKI O. [First attempt to treat tuberculosis with isonicotinic acid hydrazide]. Przegl Lek. 1952; 8(10):289-93. PMID: 13027445.
      Citations:    Fields:    
    46. FOJUDZKI E, GERWELOWA H, JONSCHER K, SKALMOWSKI T. [Treatment of epidemic infantile paralysis in the acute stage]. Pol Tyg Lek (Wars). 1951 Dec 10; 6(49-50):1573-4. PMID: 14929702.
      Citations:    Translation:PHPublic Health
    47. JONSCHER K. [Advantages and disadvantages of antibiotic therapy in pediatrics]. Pediatr Pol. 1951 Oct; 26(10):1176-87. PMID: 14891317.
      Citations:    Fields:    Translation:Humans
    48. JONSCHER K, SZCZEPSKI L. [Quartz lamp in streptomycin therapy of tuberculous meningitis]. Pediatr Pol. 1950 Dec; 24(12):1067-73. PMID: 14807615.
      Citations:    Fields:    
    49. JONSCHER K. Prophylaxis and importance of childhood tuberculosis. Arch Kinderheilkd. 1948; 134(4):233. PMID: 18916928.
      Citations:    Fields:    Translation:Humans
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