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Rakhi Rajan

TitleAssistant Professor
InstitutionUniversity of Oklahoma, Norman
620 Parrington Oval
Norman OK 73019
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Newsom SN, Wang DS, Rostami S, Schuster I, Parameshwaran HP, Joseph YG, Qin PZ, Liu J, Rajan R. Differential Divalent Metal Binding by SpyCas9's RuvC Active Site Contributes to Nonspecific DNA Cleavage. CRISPR J. 2023 Dec; 6(6):527-542. PMID: 38108519.
      Citations:    Fields:    Translation:Cells
    2. Martin L, Rostami S, Rajan R. Optimized protocols for the characterization of Cas12a activities. Methods Enzymol. 2023; 679:97-129. PMID: 36682874.
      Citations:    Fields:    Translation:Cells
    3. Flusche T, Rajan R. Molecular Details of DNA Integration by CRISPR-Associated Proteins During Adaptation in Bacteria and Archaea. Adv Exp Med Biol. 2022 Jul 20. PMID: 35852729.
      Citations: 2     Fields:    Translation:Cells
    4. Zuo Z, Babu K, Ganguly C, Zolekar A, Newsom S, Rajan R, Wang YC, Liu J. Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects. CRISPR J. 2022 04; 5(2):329-340. PMID: 35438515.
      Citations: 5     Fields:    Translation:HumansCells
    5. Babu K, Kathiresan V, Kumari P, Newsom S, Parameshwaran HP, Chen X, Liu J, Qin PZ, Rajan R. Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence. Biochemistry. 2021 12 14; 60(49):3783-3800. PMID: 34757726.
      Citations: 4     Fields:    Translation:Cells
    6. Parameshwaran HP, Babu K, Tran C, Guan K, Allen A, Kathiresan V, Qin PZ, Rajan R. The bridge helix of Cas12a imparts selectivity in cis-DNA cleavage and regulates trans-DNA cleavage. FEBS Lett. 2021 04; 595(7):892-912. PMID: 33523494.
      Citations: 5     Fields:    Translation:Cells
    7. Newsom S, Parameshwaran HP, Martin L, Rajan R. The CRISPR-Cas Mechanism for Adaptive Immunity and Alternate Bacterial Functions Fuels Diverse Biotechnologies. Front Cell Infect Microbiol. 2020; 10:619763. PMID: 33585286.
      Citations: 19     Fields:    Translation:Cells
    8. Van Orden MJ, Newsom S, Rajan R. CRISPR type II-A subgroups exhibit phylogenetically distinct mechanisms for prespacer insertion. J Biol Chem. 2020 08 07; 295(32):10956-10968. PMID: 32513871.
      Citations: 4     Fields:    Translation:Cells
    9. Jiang W, Singh J, Allen A, Li Y, Kathiresan V, Qureshi O, Tangprasertchai N, Zhang X, Parameshwaran HP, Rajan R, Qin PZ. CRISPR-Cas12a Nucleases Bind Flexible DNA Duplexes without RNA/DNA Complementarity. ACS Omega. 2019 Oct 22; 4(17):17140-17147. PMID: 31656887.
      Citations: 6     
    10. Zuo Z, Zolekar A, Babu K, Lin VJ, Hayatshahi HS, Rajan R, Wang YC, Liu J. Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain. Elife. 2019 07 30; 8. PMID: 31361218.
      Citations: 16     Fields:    Translation:Cells
    11. Babu K, Amrani N, Jiang W, Yogesha SD, Nguyen R, Qin PZ, Rajan R. Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance. Biochemistry. 2019 04 09; 58(14):1905-1917. PMID: 30916546.
      Citations: 17     Fields:    Translation:Cells
    12. Sundaresan R, Parameshwaran HP, Yogesha SD, Keilbarth MW, Rajan R. RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a. Cell Rep. 2017 12 26; 21(13):3728-3739. PMID: 29281823.
      Citations: 37     Fields:    Translation:Cells
    13. Murugan K, Babu K, Sundaresan R, Rajan R, Sashital DG. The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit. Mol Cell. 2017 Oct 05; 68(1):15-25. PMID: 28985502.
      Citations: 83     Fields:    Translation:HumansCells
    14. Van Orden MJ, Klein P, Babu K, Najar FZ, Rajan R. Conserved DNA motifs in the type II-A CRISPR leader region. PeerJ. 2017; 5:e3161. PMID: 28392985.
      Citations: 4     Fields:    
    15. Vazquez Reyes C, Tangprasertchai NS, Yogesha SD, Nguyen RH, Zhang X, Rajan R, Qin PZ. Nucleic Acid-Dependent Conformational Changes in CRISPR-Cas9 Revealed by Site-Directed Spin Labeling. Cell Biochem Biophys. 2017 Jun; 75(2):203-210. PMID: 27342128.
      Citations: 3     Fields:    Translation:Cells
    16. Zhang Y, Rajan R, Seifert HS, Mondragón A, Sontheimer EJ. DNase H Activity of Neisseria meningitidis Cas9. Mol Cell. 2015 Oct 15; 60(2):242-55. PMID: 26474066.
      Citations: 32     Fields:    Translation:Cells
    17. Wakefield N, Rajan R, Sontheimer EJ. Primary processing of CRISPR RNA by the endonuclease Cas6 in Staphylococcus epidermidis. FEBS Lett. 2015 Oct 07; 589(20 Pt B):3197-204. PMID: 26364721.
      Citations: 4     Fields:    Translation:Cells
    18. Gopishetty B, Zhu J, Rajan R, Sobczak AJ, Wnuk SF, Bell CE, Pei D. Probing the catalytic mechanism of S-ribosylhomocysteinase (LuxS) with catalytic intermediates and substrate analogues. J Am Chem Soc. 2009 Jan 28; 131(3):1243-50. PMID: 19099445.
      Citations: 21     Fields:    Translation:Cells
    19. Rajan R, Zhu J, Hu X, Pei D, Bell CE. Crystal structure of S-ribosylhomocysteinase (LuxS) in complex with a catalytic 2-ketone intermediate. Biochemistry. 2005 Mar 15; 44(10):3745-53. PMID: 15751951.
      Citations: 23     Fields:    Translation:Cells
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