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Sreemathi Logan

TitleProf,Asst
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
AddressBMSB 1305
940 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-7622 ext 47812
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    R00AG056662     (LOGAN, SREEMATHI)Sep 1, 2020 - Aug 31, 2023
    NIH
    IGF-1 Regulation of Astrocyte Mitochondrial Metabolism and Redox Homeostasis in Brain Aging
    Role: Principal Investigator
    K99AG056662     (LOGAN, SREEMATHI)Sep 30, 2018 - Aug 31, 2020
    NIH
    IGF-1 Regulation of Astrocyte Mitochondrial Metabolism and Redox Homeostasis in Brain Aging
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kotey SK, Tan X, Fleming O, Kasiraju RR, Dagnell AL, Van Pelt KN, Rogers J, Hartson SD, Thadathil N, Selvarani R, Ranjit R, Logan S, Deepa SS, Richardson A, Cheng Y. Intracellular iron accumulation facilitates mycobacterial infection in old mouse macrophages. Geroscience. 2024 Apr; 46(2):2739-2754. PMID: 38159133.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Rose HM, Ferr?n B, Ranjit R, Masingale AM, Owen DB, Hussong S, Kinter MT, Galvan V, Logan S, D?az-Garc?a CM. Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning. J Neurochem. 2023 Jul 06. PMID: 37415312.
      Citations:    Fields:    
    3. Mondal SA, Mann SN, van der Linden C, Sathiaseelan R, Kamal M, Das S, Bubak MP, Logan S, Miller BF, Stout MB. Metabolic benefits of 17a-estradiol in liver are partially mediated by ER? in male mice. Sci Rep. 2023 Jun 17; 13(1):9841. PMID: 37330610; PMCID: PMC10276872.
      Citations:    Fields:    Translation:AnimalsCells
    4. Cassidy BR, Logan S, Farley JA, Owen DB, Sonntag WE, Drevets DA. Progressive cognitive impairment after recovery from neuroinvasive and non-neuroinvasive Listeria monocytogenes infection. Front Immunol. 2023; 14:1146690. PMID: 37143648; PMCID: PMC10151798.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Logan S, Baier MP, Owen DB, Peasari J, Jones KL, Ranjit R, Yarbrough HP, Masingale AM, Bhandari S, Rice HC, Kinter MT, Sonntag WE. Cognitive heterogeneity reveals molecular signatures of age-related impairment. PNAS Nexus. 2023 Apr; 2(4):pgad101. PMID: 37091543; PMCID: PMC10118303.
      Citations: 1     
    6. Mondal SA, Mann SN, van der Linden C, Sathiaseelan R, Kamal M, Das S, Bubak MP, Logan S, Miller BF, Stout MB. Metabolic benefits of 17a-estradiol in liver are partially mediated by ER? in male mice. bioRxiv. 2023 Mar 25. PMID: 36993459; PMCID: PMC10055366.
      Citations:    
    7. Sathiaseelan R, Ahn B, Stout MB, Logan S, Wanagat J, Van M Nguyen H, Hord NG, Vandiver AR, Selvarani R, Ranjit R, Yarbrough H, Masingale A, Miller BF, Wolf RF, Austad SN, Richardson A. A Genetically Heterogeneous Rat Model with Divergent Mitochondrial Genomes. J Gerontol A Biol Sci Med Sci. 2023 Feb 10. PMID: 36762848.
      Citations: 2     Fields:    Translation:HumansAnimals
    8. Baier MP, Nagaraja RY, Yarbrough HP, Owen DB, Masingale AM, Ranjit R, Stiles MA, Murphy A, Agbaga MP, Ahmad M, Sherry DM, Kinter MT, Van Remmen H, Logan S. Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis. J Neurosci. 2022 08 03; 42(31):5992-6006. PMID: 35760531.
      Citations: 6     Fields:    Translation:AnimalsCells
    9. Grieco F, Bernstein BJ, Biemans B, Bikovski L, Burnett CJ, Cushman JD, van Dam EA, Fry SA, Richmond-Hacham B, Homberg JR, Kas MJH, Kessels HW, Koopmans B, Krashes MJ, Krishnan V, Logan S, Loos M, McCann KE, Parduzi Q, Pick CG, Prevot TD, Riedel G, Robinson L, Sadighi M, Smit AB, Sonntag W, Roelofs RF, Tegelenbosch RAJ, Noldus LPJJ. Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives. Front Behav Neurosci. 2021; 15:735387. PMID: 34630052.
      Citations: 26     
    10. Tarantini S, Balasubramanian P, Yabluchanskiy A, Ashpole NM, Logan S, Kiss T, Ungvari A, Nyúl-Tóth Á, Schwartzman ML, Benyo Z, Sonntag WE, Csiszar A, Ungvari Z. IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging. Geroscience. 2021 04; 43(2):901-911. PMID: 33674953.
      Citations: 19     Fields:    Translation:AnimalsCells
    11. Orock A, Logan S, Deak F. Age-Related Cognitive Impairment: Role of Reduced Synaptobrevin-2 Levels in Deficits of Memory and Synaptic Plasticity. J Gerontol A Biol Sci Med Sci. 2020 09 16; 75(9):1624-1632. PMID: 30649208.
      Citations: 6     Fields:    Translation:Animals
    12. Parks EE, Logan S, Yeganeh A, Farley JA, Owen DB, Sonntag WE. Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice. J Lipid Res. 2020 10; 61(10):1308-1319. PMID: 32669383.
      Citations: 8     Fields:    Translation:Animals
    13. Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S. Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function. Mol Neurobiol. 2020 Mar; 57(3):1317-1331. PMID: 31732912.
      Citations: 16     Fields:    Translation:AnimalsCells
    14. Logan S, Royce GH, Owen D, Farley J, Ranjo-Bishop M, Sonntag WE, Deepa SS. Accelerated decline in cognition in a mouse model of increased oxidative stress. Geroscience. 2019 10; 41(5):591-607. PMID: 31641924.
      Citations: 20     Fields:    Translation:Animals
    15. Lee YI, Kim YG, Pyeon HJ, Ahn JC, Logan S, Orock A, Joo KM, Lorincz A, Deák F. Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain. Geroscience. 2019 04; 41(2):109-123. PMID: 31041658.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    16. Logan S, Owen D, Chen S, Chen WJ, Ungvari Z, Farley J, Csiszar A, Sharpe A, Loos M, Koopmans B, Richardson A, Sonntag WE. Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice. Geroscience. 2018 04; 40(2):123-137. PMID: 29687240.
      Citations: 23     Fields:    Translation:Animals
    17. Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE. Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-ß uptake in astrocytes. Mol Metab. 2018 03; 9:141-155. PMID: 29398615.
      Citations: 71     Fields:    Translation:AnimalsCells
    18. Orock A, Logan S, Deak F. Munc18-1 haploinsufficiency impairs learning and memory by reduced synaptic vesicular release in a model of Ohtahara syndrome. Mol Cell Neurosci. 2018 04; 88:33-42. PMID: 29217410.
      Citations: 21     Fields:    Translation:AnimalsCells
    19. Ashpole NM, Logan S, Yabluchanskiy A, Mitschelen MC, Yan H, Farley JA, Hodges EL, Ungvari Z, Csiszar A, Chen S, Georgescu C, Hubbard GB, Ikeno Y, Sonntag WE. IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. Geroscience. 2017 04; 39(2):129-145. PMID: 28409331.
      Citations: 82     Fields:    Translation:Animals
    20. Ungvari Z, Tarantini S, Hertelendy P, Valcarcel-Ares MN, Fülöp GA, Logan S, Kiss T, Farkas E, Csiszar A, Yabluchanskiy A. Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence. Geroscience. 2017 02; 39(1):33-42. PMID: 28299642.
      Citations: 64     Fields:    Translation:AnimalsPHPublic Health
    21. Hadad N, Masser DR, Logan S, Wronowski B, Mangold CA, Clark N, Otalora L, Unnikrishnan A, Ford MM, Giles CB, Wren JD, Richardson A, Sonntag WE, Stanford DR, Freeman W. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics Chromatin. 2016; 9:30. PMID: 27413395.
      Citations: 32     Fields:    
    22. Ashpole NM, Herron JC, Estep PN, Logan S, Hodges EL, Yabluchanskiy A, Humphrey MB, Sonntag WE. Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice. Age (Dordr). 2016 Apr; 38(2):38. PMID: 26968399.
      Citations: 15     Fields:    Translation:Animals
    23. Ashpole NM, Herron JC, Mitschelen MC, Farley JA, Logan S, Yan H, Ungvari Z, Hodges EL, Csiszar A, Ikeno Y, Humphrey MB, Sonntag WE. IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. J Bone Miner Res. 2016 Feb; 31(2):443-54. PMID: 26260312.
      Citations: 26     Fields:    Translation:AnimalsCells
    24. Brock AJ, Kasus-Jacobi A, Lerner M, Logan S, Adesina AM, Anne Pereira H. The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease. Histochem Cell Biol. 2015 Oct; 144(4):293-308. PMID: 26170148.
      Citations: 9     Fields:    Translation:HumansCells
    25. Logan S, Agbaga MP, Chan MD, Brush RS, Anderson RE. Endoplasmic reticulum microenvironment and conserved histidines govern ELOVL4 fatty acid elongase activity. J Lipid Res. 2014 Apr; 55(4):698-708. PMID: 24569140.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    26. Logan S, Anderson RE. Dominant Stargardt Macular Dystrophy (STGD3) and ELOVL4. Adv Exp Med Biol. 2014; 801:447-53. PMID: 24664730.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    27. Agbaga MP, Logan S, Brush RS, Anderson RE. Biosynthesis of very long-chain polyunsaturated fatty acids in hepatocytes expressing ELOVL4. Adv Exp Med Biol. 2014; 801:631-6. PMID: 24664752.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    28. Griffith GL, Russell RA, Kasus-Jacobi A, Thavathiru E, Gonzalez ML, Logan S, Pereira HA. CAP37 activation of PKC promotes human corneal epithelial cell chemotaxis. Invest Ophthalmol Vis Sci. 2013 Oct 15; 54(10):6712-23. PMID: 24008408.
      Citations: 12     Fields:    Translation:HumansCells
    29. Logan S, Agbaga MP, Chan MD, Kabir N, Mandal NA, Brush RS, Anderson RE. Deciphering mutant ELOVL4 activity in autosomal-dominant Stargardt macular dystrophy. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5446-51. PMID: 23509295.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    30. Yu M, Benham A, Logan S, Brush RS, Mandal MNA, Anderson RE, Agbaga MP. ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3. J Lipid Res. 2012 Mar; 53(3):494-504. PMID: 22158834.
      Citations: 37     Fields:    Translation:AnimalsCells
    31. Pereira HA, Tsyshevskaya-Hoover I, Hinsley H, Logan S, Nguyen M, Nguyen TT, Pohl J, Wozniak K, Fidel PL. Candidacidal activity of synthetic peptides based on the antimicrobial domain of the neutrophil-derived protein, CAP37. Med Mycol. 2010 Mar; 48(2):263-72. PMID: 19626550.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    32. Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. J Neurosci. 2007 Apr 04; 27(14):3639-49. PMID: 17409228.
      Citations: 204     Fields:    Translation:HumansAnimalsCells
    33. Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci. 2006 Oct 04; 26(40):10129-40. PMID: 17021169.
      Citations: 1518     Fields:    Translation:AnimalsCells
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