"Trypsin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
| Descriptor ID |
D014357
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| MeSH Number(s) |
D08.811.277.656.300.760.895 D08.811.277.656.959.350.895
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Trypsin".
Below are MeSH descriptors whose meaning is more specific than "Trypsin".
This graph shows the total number of publications written about "Trypsin" by people in this website by year, and whether "Trypsin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2001 | 1 | 1 | 2 |
| 2002 | 1 | 3 | 4 |
| 2004 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 2 | 2 |
| 2013 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Trypsin" by people in Profiles.
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RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a. Cell Rep. 2017 12 26; 21(13):3728-3739.
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Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease. J Enzyme Inhib Med Chem. 2016; 31(sup2):194-200.
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Structural modeling and physicochemical characterization provide evidence that P66 forms a ß-barrel in the Borrelia burgdorferi outer membrane. J Bacteriol. 2014 Feb; 196(4):859-72.
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Pathogenic role of diabetes-induced PPAR-a down-regulation in microvascular dysfunction. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15401-6.
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Disulfide-bond scanning reveals assembly state and ß-strand tilt angle of the PFO ß-barrel. Nat Chem Biol. 2013 Jun; 9(6):383-9.
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Proteasome inhibition 1 h following ischemia protects GRK2 and prevents malignant ventricular tachyarrhythmias and SCD in a model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1298-303.
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Biomarker identification in human pancreatic cancer sera. Pancreas. 2008 Jan; 36(1):61-9.
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Novel eye-specific calmodulin methylation characterized by protein mapping in Drosophila melanogaster. Proteomics. 2007 Aug; 7(15):2651-8.
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Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds. Bioorg Med Chem. 2007 Jul 01; 15(13):4618-28.
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Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin. Nat Struct Mol Biol. 2004 Dec; 11(12):1173-8.