Header Logo

Augen A Pioszak

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
AddressBRC 464
975 NE 10th St
Oklahoma City OK 73104
Phone405/271-2401
Fax0
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R01GM104251     (PIOSZAK, AUGEN A)Sep 26, 2012 - Aug 31, 2021
    NIH
    RAMP-altered class B GPCR hormone recognition
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lee S, Pioszak AA. Molecular interaction of an antagonistic amylin analog with the extracellular domain of receptor activity-modifying protein 2 assessed by fluorescence polarization. Biophys Chem. 2020 12; 267:106477. PMID: 33137565.
      Citations: 1     Fields:    
    2. Booe JM, Warner ML, Pioszak AA. Picomolar Affinity Antagonist and Sustained Signaling Agonist Peptide Ligands for the Adrenomedullin and Calcitonin Gene-Related Peptide Receptors. ACS Pharmacol Transl Sci. 2020 Aug 14; 3(4):759-772. PMID: 32832875.
      Citations:    
    3. Roehrkasse AM, Warner ML, Booe JM, Pioszak AA. Biochemical characterization of G protein coupling to calcitonin gene-related peptide and adrenomedullin receptors using a native PAGE assay. J Biol Chem. 2020 07 10; 295(28):9736-9751. PMID: 32487746.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Hendrikse ER, Liew LP, Bower RL, Bonnet M, Jamaluddin MA, Prodan N, Richards KD, Walker CS, Pairaudeau G, Smith DM, Rujan RM, Sudra R, Reynolds CA, Booe JM, Pioszak AA, Flanagan JU, Hay MP, Hay DL. Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors. ACS Pharmacol Transl Sci. 2020 Apr 10; 3(2):305-320. PMID: 32296770.
      Citations:    
    5. Lee SM, Jeong Y, Simms J, Warner ML, Poyner DR, Chung KY, Pioszak AA. Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics. J Mol Biol. 2020 03 27; 432(7):1996-2014. PMID: 32035902.
      Citations: 4     Fields:    Translation:HumansCells
    6. Pioszak AA, Hay DL. RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors. Adv Pharmacol. 2020; 88:115-141. PMID: 32416865.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    7. Roehrkasse AM, Booe JM, Lee SM, Warner ML, Pioszak AA. Structure-function analyses reveal a triple ß-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design. J Biol Chem. 2018 10 12; 293(41):15840-15854. PMID: 30139742.
      Citations: 7     Fields:    Translation:HumansCells
    8. Bower RL, Yule L, Rees TA, Deganutti G, Hendrikse ER, Harris PWR, Kowalczyk R, Ridgway Z, Wong AG, Swierkula K, Raleigh DP, Pioszak AA, Brimble MA, Reynolds CA, Walker CS, Hay DL. Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin. ACS Pharmacol Transl Sci. 2018 Sep 14; 1(1):32-49. PMID: 32219203.
      Citations:    
    9. Booe JM, Warner ML, Roehrkasse AM, Hay DL, Pioszak AA. Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. Mol Pharmacol. 2018 04; 93(4):355-367. PMID: 29363552.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    10. Lee SM, Booe JM, Gingell JJ, Sjoelund V, Hay DL, Pioszak AA. N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity. Biochemistry. 2017 07 05; 56(26):3380-3393. PMID: 28614667.
      Citations: 9     Fields:    Translation:HumansCells
    11. Lee SM, Hay DL, Pioszak AA. Calcitonin and amylin receptor peptide interaction mechanisms. INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS. J Biol Chem. 2016 07 29; 291(31):16416. PMID: 27474777.
      Citations:    Fields:    
    12. Gingell JJ, Simms J, Barwell J, Poyner DR, Watkins HA, Pioszak AA, Sexton PM, Hay DL. Erratum: An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. Cell Discov. 2016; 2:16020. PMID: 27463403.
      Citations:    
    13. J Gingell J, Simms J, Barwell J, Poyner DR, Watkins HA, Pioszak AA, Sexton PM, Hay DL. An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. Cell Discov. 2016; 2:16012. PMID: 27462459.
      Citations:    
    14. Watkins HA, Chakravarthy M, Abhayawardana RS, Gingell JJ, Garelja M, Pardamwar M, McElhinney JM, Lathbridge A, Constantine A, Harris PW, Yuen TY, Brimble MA, Barwell J, Poyner DR, Woolley MJ, Conner AC, Pioszak AA, Reynolds CA, Hay DL. Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. J Biol Chem. 2016 May 27; 291(22):11657-75. PMID: 27013657.
      Citations: 19     Fields:    Translation:HumansCells
    15. Lee SM, Hay DL, Pioszak AA. Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS. J Biol Chem. 2016 Apr 15; 291(16):8686-700. PMID: 26895962.
      Citations: 18     Fields:    Translation:HumansCells
    16. Hay DL, Pioszak AA. Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles. Annu Rev Pharmacol Toxicol. 2016; 56:469-87. PMID: 26514202.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    17. Lee SM, Booe JM, Pioszak AA. Structural insights into ligand recognition and selectivity for classes A, B, and C GPCRs. Eur J Pharmacol. 2015 Sep 15; 763(Pt B):196-205. PMID: 25981303.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    18. Booe JM, Walker CS, Barwell J, Kuteyi G, Simms J, Jamaluddin MA, Warner ML, Bill RM, Harris PW, Brimble MA, Poyner DR, Hay DL, Pioszak AA. Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Mol Cell. 2015 Jun 18; 58(6):1040-52. PMID: 25982113.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    19. Warner ML, Bell T, Pioszak AA. Engineering high-potency R-spondin adult stem cell growth factors. Mol Pharmacol. 2015; 87(3):410-20. PMID: 25504990.
      Citations: 9     Fields:    Translation:HumansCells
    20. Moad HE, Pioszak AA. Selective CGRP and adrenomedullin peptide binding by tethered RAMP-calcitonin receptor-like receptor extracellular domain fusion proteins. Protein Sci. 2013 Dec; 22(12):1775-85. PMID: 24115156.
      Citations: 16     Fields:    Translation:HumansCells
    21. Moad HE, Pioszak AA. Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli. Biochemistry. 2013 Oct 15; 52(41):7295-304. PMID: 24050775.
      Citations: 16     Fields:    Translation:Cells
    22. Hill HE, Pioszak AA. Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling. Protein Expr Purif. 2013 Mar; 88(1):107-13. PMID: 23247088.
      Citations: 10     Fields:    Translation:HumansCells
    23. Kumar S, Pioszak A, Zhang C, Swaminathan K, Xu HE. Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors. PLoS One. 2011; 6(5):e19682. PMID: 21625560.
      Citations: 32     Fields:    Translation:HumansCells
    24. Pal K, Swaminathan K, Xu HE, Pioszak AA. Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor. J Biol Chem. 2010 Dec 17; 285(51):40351-61. PMID: 20966082.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    25. Pioszak AA, Harikumar KG, Parker NR, Miller LJ, Xu HE. Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation. J Biol Chem. 2010 Apr 16; 285(16):12435-44. PMID: 20172855.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    26. Pioszak AA, Parker NR, Gardella TJ, Xu HE. Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptides. J Biol Chem. 2009 Oct 09; 284(41):28382-28391. PMID: 19674967.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    27. Pioszak AA, Parker NR, Suino-Powell K, Xu HE. Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1. J Biol Chem. 2008 Nov 21; 283(47):32900-12. PMID: 18801728.
      Citations: 80     Fields:    Translation:HumansCells
    28. Pioszak AA, Xu HE. Molecular recognition of parathyroid hormone by its G protein-coupled receptor. Proc Natl Acad Sci U S A. 2008 Apr 01; 105(13):5034-9. PMID: 18375760.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    29. Jiang P, Pioszak AA, Ninfa AJ. Structure-function analysis of glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49) of Escherichia coli. Biochemistry. 2007 Apr 03; 46(13):4117-32. PMID: 17355124.
      Citations: 9     Fields:    Translation:Cells
    30. Pioszak AA, Murayama K, Nakagawa N, Ebihara A, Kuramitsu S, Shirouzu M, Yokoyama S. Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 01; 61(Pt 10):867-74. PMID: 16511182.
      Citations: 3     Fields:    Translation:Cells
    31. Pioszak AA, Ninfa AJ. Mutations altering the N-terminal receiver domain of NRI (NtrC) That prevent dephosphorylation by the NRII-PII complex in Escherichia coli. J Bacteriol. 2004 Sep; 186(17):5730-40. PMID: 15317778.
      Citations: 15     Fields:    Translation:Cells
    32. Song Y, Peisach D, Pioszak AA, Xu Z, Ninfa AJ. Crystal structure of the C-terminal domain of the two-component system transmitter protein nitrogen regulator II (NRII; NtrB), regulator of nitrogen assimilation in Escherichia coli. Biochemistry. 2004 Jun 01; 43(21):6670-8. PMID: 15157101.
      Citations: 14     Fields:    Translation:Cells
    33. Pioszak AA, Ninfa AJ. Mechanism of the PII-activated phosphatase activity of Escherichia coli NRII (NtrB): how the different domains of NRII collaborate to act as a phosphatase. Biochemistry. 2003 Jul 29; 42(29):8885-99. PMID: 12873150.
      Citations: 17     Fields:    Translation:Cells
    34. Pioszak AA, Ninfa AJ. Genetic and biochemical analysis of phosphatase activity of Escherichia coli NRII (NtrB) and its regulation by the PII signal transduction protein. J Bacteriol. 2003 Feb; 185(4):1299-315. PMID: 12562801.
      Citations: 18     Fields:    Translation:Cells
    35. Pioszak AA, Jiang P, Ninfa AJ. The Escherichia coli PII signal transduction protein regulates the activities of the two-component system transmitter protein NRII by direct interaction with the kinase domain of the transmitter module. Biochemistry. 2000 Nov 07; 39(44):13450-61. PMID: 11063581.
      Citations: 26     Fields:    Translation:Cells
    Pioszak's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (145)
    Explore
    _
    Co-Authors (2)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _