Transforming Growth Factor beta

"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Descriptor ID	D016212
MeSH Number(s)	D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
Concept/Terms	Transforming Growth Factor beta Transforming Growth Factor beta Milk Growth Factor Factor, Milk Growth Growth Factor, Milk TGF-beta TGFbeta Platelet Transforming Growth Factor Bone-Derived Transforming Growth Factor Bone Derived Transforming Growth Factor

Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Transforming Growth Factor beta [D12.644.276.374.687]
TGF-beta Superfamily Proteins [D12.644.276.954]
Transforming Growth Factor beta [D12.644.276.954.775]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Transforming Growth Factor beta [D12.776.467.374.687]
TGF-beta Superfamily Proteins [D12.776.467.942]
Transforming Growth Factor beta [D12.776.467.942.775]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Transforming Growth Factor beta [D23.529.374.687]
TGF-beta Superfamily Proteins [D23.529.942]
Transforming Growth Factor beta [D23.529.942.775]

Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.

Bar chart showing 46 publications over 20 distinct years, with a maximum of 5 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	1	2
1998	1	0	1
1999	1	0	1
2000	2	0	2
2002	3	1	4
2003	1	0	1
2005	4	1	5
2006	1	1	2
2008	1	2	3
2009	3	0	3
2010	1	0	1
2011	1	0	1
2012	0	2	2
2013	3	1	4
2014	1	2	3
2015	2	2	4
2016	0	2	2
2017	2	0	2
2018	0	2	2
2021	0	1	1

Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.

Pazhani J, Jayaraman S, Veeraraghavan VP, Somasundaram DB, Raj AT, Patil S. Targeting cancer associated fibroblasts - A TGF-ß based immunotherapy for head and neck squamous cell carcinoma. Oral Oncol. 2022 Jul; 130:105899.

View in: PubMed
Shi X, Yang J, Liu M, Zhang Y, Zhou Z, Luo W, Fung KM, Xu C, Bronze MS, Houchen CW, Li M. Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-ß Signaling Axis in Pancreatic Cancer. Gastroenterology. 2022 Jun; 162(7):2004-2017.e2.

View in: PubMed
Ma X, Takahashi Y, Wu W, Chen J, Dehdarani M, Liang W, Shin YH, Benyajati S, Ma JX. Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration. FASEB J. 2021 12; 35(12):e22058.

View in: PubMed
Raguraman R, Srivastava A, Munshi A, Ramesh R. Therapeutic approaches targeting molecular signaling pathways common to diabetes, lung diseases and cancer. Adv Drug Deliv Rev. 2021 11; 178:113918.

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Mandala A, Chen WJ, Armstrong A, Malhotra MR, Chavalmane S, McCommis KS, Chen A, Carpenter D, Biswas P, Gnana-Prakasam JP. PPARa agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and ß-catenin signaling. Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(4):G262-G269.

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Mamidi MK, Samsa WE, Bashur LA, Chen Y, Chan R, Lee B, Zhou G. The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity. J Cell Physiol. 2021 08; 236(8):5686-5697.

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Childers RC, Sunyecz I, West TA, Cismowski MJ, Lucchesi PA, Gooch KJ. Role of the cytoskeleton in the development of a hypofibrotic cardiac fibroblast phenotype in volume overload heart failure. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H596-H608.

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Das S, Vraspir L, Zhou W, Durica DS, Mykles DL. Transcriptomic analysis of differentially expressed genes in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis, during molt-cycle stage transitions. Comp Biochem Physiol Part D Genomics Proteomics. 2018 12; 28:37-53.

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Gallucci RM. Transforming growth factor-ß and psoriasis: a new link. Br J Dermatol. 2017 12; 177(6):1480-1481.

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Kim SK, Barron L, Hinck CS, Petrunak EM, Cano KE, Thangirala A, Iskra B, Brothers M, Vonberg M, Leal B, Richter B, Kodali R, Taylor AB, Du S, Barnes CO, Sulea T, Calero G, Hart PJ, Hart MJ, Demeler B, Hinck AP. An engineered transforming growth factor ß (TGF-ß) monomer that functions as a dominant negative to block TGF-ß signaling. J Biol Chem. 2017 04 28; 292(17):7173-7188.

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