Transforming Growth Factor beta

"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Descriptor ID	D016212
MeSH Number(s)	D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
Concept/Terms	Transforming Growth Factor beta Transforming Growth Factor beta Milk Growth Factor Factor, Milk Growth Growth Factor, Milk TGF-beta TGFbeta Platelet Transforming Growth Factor Bone-Derived Transforming Growth Factor Bone Derived Transforming Growth Factor

Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Transforming Growth Factor beta [D12.644.276.374.687]
TGF-beta Superfamily Proteins [D12.644.276.954]
Transforming Growth Factor beta [D12.644.276.954.775]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Transforming Growth Factor beta [D12.776.467.374.687]
TGF-beta Superfamily Proteins [D12.776.467.942]
Transforming Growth Factor beta [D12.776.467.942.775]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Transforming Growth Factor beta [D23.529.374.687]
TGF-beta Superfamily Proteins [D23.529.942]
Transforming Growth Factor beta [D23.529.942.775]

Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.

Bar chart showing 52 publications over 22 distinct years, with a maximum of 5 publications in 2002 and 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	1	2
1998	1	0	1
1999	1	0	1
2000	2	0	2
2001	0	1	1
2002	4	1	5
2003	1	0	1
2004	0	1	1
2005	4	1	5
2006	3	1	4
2008	1	2	3
2009	3	0	3
2010	1	0	1
2011	1	0	1
2012	0	2	2
2013	3	1	4
2014	1	2	3
2015	2	2	4
2016	0	3	3
2017	2	0	2
2018	0	2	2
2019	0	1	1

Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.

Chen Y, Zhang Q, Wu Y, Branch-Brooks CD, Butler CE. Short-term influences of radiation on musculofascial healing in a laparotomy rat model. Sci Rep. 2019 08 15; 9(1):11896.

View in: PubMed
Childers RC, Sunyecz I, West TA, Cismowski MJ, Lucchesi PA, Gooch KJ. Role of the cytoskeleton in the development of a hypofibrotic cardiac fibroblast phenotype in volume overload heart failure. . 2019 03 01; 316(3):H596-H608.

View in: PubMed
Das S, Vraspir L, Zhou W, Durica DS, Mykles DL. Transcriptomic analysis of differentially expressed genes in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis, during molt-cycle stage transitions. Comp Biochem Physiol Part D Genomics Proteomics. 2018 12; 28:37-53.

View in: PubMed
Gallucci RM. Transforming growth factor-ß and psoriasis: a new link. Br J Dermatol. 2017 12; 177(6):1480-1481.

View in: PubMed
Oliveira SDS, Castellon M, Chen J, Bonini MG, Gu X, Elliott MH, Machado RF, Minshall RD. Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-ß-driven pulmonary vascular remodeling. . 2017 05 01; 312(5):L760-L771.

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Zhu H, Zhang M, Liu Z, Xing J, Moriasi C, Dai X, Zou MH. AMP-Activated Protein Kinase a1 in Macrophages Promotes Collateral Remodeling and Arteriogenesis in Mice In Vivo. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1868-78.

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Krishnan P, Purushothaman KR, Purushothaman M, Turnbull IC, Tarricone A, Vasquez M, Jain S, Baber U, Lascano RA, Kini AS, Sharma SK, Moreno PR. Enhanced neointimal fibroblast, myofibroblast content and altered extracellular matrix composition: Implications in the progression of human peripheral artery restenosis. Atherosclerosis. 2016 08; 251:226-233.

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Zimmerman KA, Xing D, Pallero MA, Lu A, Ikawa M, Black L, Hoyt KL, Kabarowski JH, Michalak M, Murphy-Ullrich JE. Calreticulin Regulates Neointima Formation and Collagen Deposition following Carotid Artery Ligation. J Vasc Res. 2015; 52(5):306-20.

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Mohan N, Gupta V, Sridharan BP, Mellott AJ, Easley JT, Palmer RH, Galbraith RA, Key VH, Berkland CJ, Detamore MS. Microsphere-based gradient implants for osteochondral regeneration: a long-term study in sheep. Regen Med. 2015; 10(6):709-28.

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Dwivedi SK, McMeekin SD, Slaughter K, Bhattacharya R. Role of TGF-ß signaling in uterine carcinosarcoma. Oncotarget. 2015 Jun 10; 6(16):14646-55.

View in: PubMed

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