"Adrenomedullin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 52-amino acid peptide with multi-functions. It was originally isolated from PHEOCHROMOCYTOMA and ADRENAL MEDULLA but is widely distributed throughout the body including lung and kidney tissues. Besides controlling fluid-electrolyte homeostasis, adrenomedullin is a potent vasodilator and can inhibit pituitary ACTH secretion.
- Proadrenomedullin N-Terminal 20 Peptide
- Proadrenomedullin N Terminal 20 Peptide
- Proadrenomedullin (1-20)
Below are MeSH descriptors whose meaning is more general than "Adrenomedullin".
Below are MeSH descriptors whose meaning is more specific than "Adrenomedullin".
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Below are the most recent publications written about "Adrenomedullin" by people in Profiles.
Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival. Peptides. 2019 02; 112:96-100.
Structure-function analyses reveal a triple ß-turn receptor-bound conformation of adrenomedullin 2/intermedin and enable peptide antagonist design. J Biol Chem. 2018 10 12; 293(41):15840-15854.
Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. Mol Pharmacol. 2018 04; 93(4):355-367.
Adrenomedullin improves fertility and promotes pinopodes and cell junctions in the peri-implantation endometrium. Biol Reprod. 2017 Sep 01; 97(3):466-477.
Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. J Biol Chem. 2016 May 27; 291(22):11657-75.
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor. Mol Cell. 2015 Jun 18; 58(6):1040-52.
Selective CGRP and adrenomedullin peptide binding by tethered RAMP-calcitonin receptor-like receptor extracellular domain fusion proteins. Protein Sci. 2013 Dec; 22(12):1775-85.