CD40 Ligand

"CD40 Ligand" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.

Descriptor ID	D023201
MeSH Number(s)	D12.644.276.374.750.124 D12.776.395.550.185 D12.776.467.374.750.124 D12.776.543.550.198 D23.529.374.750.124
Concept/Terms	CD40 Ligand CD40 Ligand gp39 Antigen, T-Cell T-Cell gp39 Antigen gp39 Antigen, T Cell CD40L Tumor Necrosis Factor Ligand Superfamily Member 5 Antigen, CD154 CD154 Antigen T-B Cell Activating Molecule TNF Superfamily, Member 5 CD154 Antigens Antigens, CD154

Below are MeSH descriptors whose meaning is more general than "CD40 Ligand".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Tumor Necrosis Factors [D12.644.276.374.750]
CD40 Ligand [D12.644.276.374.750.124]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
CD40 Ligand [D12.776.395.550.185]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Tumor Necrosis Factors [D12.776.467.374.750]
CD40 Ligand [D12.776.467.374.750.124]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
CD40 Ligand [D12.776.543.550.198]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Tumor Necrosis Factors [D23.529.374.750]
CD40 Ligand [D23.529.374.750.124]

Below are MeSH descriptors whose meaning is related to "CD40 Ligand".

Below are MeSH descriptors whose meaning is more specific than "CD40 Ligand".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CD40 Ligand" by people in this website by year, and whether "CD40 Ligand" was a major or minor topic of these publications.

Bar chart showing 11 publications over 8 distinct years, with a maximum of 2 publications in 2002 and 2011 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	1	1
2000	0	1	1
2002	1	1	2
2007	1	0	1
2011	1	1	2
2013	1	0	1
2014	0	2	2

Below are the most recent publications written about "CD40 Ligand" by people in Profiles.

Shen L, Zhang H, Caimol M, Benike CJ, Chakravarty EF, Strober S, Engleman EG. Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production. Eur J Immunol. 2015 Feb; 45(2):612-23.

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Munroe ME, Vista ES, Guthridge JM, Thompson LF, Merrill JT, James JA. Proinflammatory adaptive cytokine and shed tumor necrosis factor receptor levels are elevated preceding systemic lupus erythematosus disease flare. Arthritis Rheumatol. 2014 Jul; 66(7):1888-99.

View in: PubMed
Merrill JT. Co-stimulatory molecules as targets for treatment of lupus. Clin Immunol. 2013 Sep; 148(3):369-75.

View in: PubMed
Shah HB, Joshi SK, Lang ML. CD40L-null NKT cells provide B cell help for specific antibody responses. Vaccine. 2011 Nov 15; 29(49):9132-6.

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Lang GA, Johnson AM, Devera TS, Joshi SK, Lang ML. Reduction of CD1d expression in vivo minimally affects NKT-enhanced antibody production but boosts B-cell memory. Int Immunol. 2011 Apr; 23(4):251-60.

View in: PubMed
Tran CN, Davis MJ, Tesmer LA, Endres JL, Motyl CD, Smuda C, Somers EC, Chung KC, Urquhart AG, Lundy SK, Kovats S, Fox DA. Presentation of arthritogenic peptide to antigen-specific T cells by fibroblast-like synoviocytes. Arthritis Rheum. 2007 May; 56(5):1497-506.

View in: PubMed
Huang XL, Fan Z, Zheng L, Borowski L, Li H, Thomas EK, Hildebrand WH, Zhao XQ, Rinaldo CR. Priming of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cell responses by dendritic cells loaded with HIV-1 proteins. J Infect Dis. 2003 Jan 15; 187(2):315-9.

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Kalunian KC, Davis JC, Merrill JT, Totoritis MC, Wofsy D. Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002 Dec; 46(12):3251-8.

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Hernández-Hoyos G, Sohn SJ, Rothenberg EV, Alberola-Ila J. Lck activity controls CD4/CD8 T cell lineage commitment. Immunity. 2000 Mar; 12(3):313-22.

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Tsytsykova AV, Tsitsikov EN, Geha RS. The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription. J Biol Chem. 1996 Feb 16; 271(7):3763-70.

View in: PubMed

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