Von Hippel-Lindau Tumor Suppressor Protein
"Von Hippel-Lindau Tumor Suppressor Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.
| Descriptor ID |
D051794
|
| MeSH Number(s) |
D08.811.464.938.750.875 D12.776.624.776.865
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Von Hippel-Lindau Tumor Suppressor Protein".
Below are MeSH descriptors whose meaning is more specific than "Von Hippel-Lindau Tumor Suppressor Protein".
This graph shows the total number of publications written about "Von Hippel-Lindau Tumor Suppressor Protein" by people in this website by year, and whether "Von Hippel-Lindau Tumor Suppressor Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Von Hippel-Lindau Tumor Suppressor Protein" by people in Profiles.
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Squalene deters drivers of RCC disease progression beyond VHL status. Cell Biol Toxicol. 2021 08; 37(4):611-631.
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Biomarkers of Targeted Therapy and Immuno-Oncology in Cancers Metastatic to the Breast. Appl Immunohistochem Mol Morphol. 2020 10; 28(9):661-668.
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E3 Ubiquitin Ligase Von Hippel-Lindau Protein Promotes Th17 Differentiation. J Immunol. 2020 08 15; 205(4):1009-1023.
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Low frequency of HIF-1a overexpression in germ cell tumors of the testis. Appl Immunohistochem Mol Morphol. 2013 Mar; 21(2):165-9.
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Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet. 2012 Dec 15; 21(26):5456-71.
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Activation of peroxisome proliferator-activated receptor a (PPARa) suppresses hypoxia-inducible factor-1a (HIF-1a) signaling in cancer cells. J Biol Chem. 2012 Oct 12; 287(42):35161-35169.
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Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21188-93.
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Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2011 Jul 29; 52(8):5872-80.
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Renal medullary carcinomas: histopathologic phenotype associated with diverse genotypes. Hum Pathol. 2011 Dec; 42(12):1979-88.
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Clinical and molecular features of familial and sporadic cases of von Hippel-Lindau disease from Mexico. Clin Exp Ophthalmol. 2010 Apr; 38(3):277-83.