Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR.
Thavathiru E, Ludes-Meyers JH, MacLeod MC, Aldaz CM. Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR. Mol Carcinog. 2005 Nov; 44(3):174-82.
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7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
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7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
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Acid Anhydride Hydrolases
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Acid Anhydride Hydrolases
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Carcinogens, Environmental
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Carcinogens, Environmental
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Cell Line, Tumor
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Cell Line, Tumor
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Chromosome Fragile Sites
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Chromosome Fragile Sites
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Down-Regulation
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Down-Regulation
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Gene Expression Regulation, Neoplastic
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Gene Expression Regulation, Neoplastic
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Humans
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Humans
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Neoplasm Proteins
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Neoplasm Proteins
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Oxidoreductases
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Oxidoreductases
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Radiation, Ionizing
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Radiation, Ionizing
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Tumor Suppressor Protein p53
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Tumor Suppressor Protein p53
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Tumor Suppressor Proteins
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Tumor Suppressor Proteins
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Ultraviolet Rays
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Ultraviolet Rays
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WW Domain-Containing Oxidoreductase
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WW Domain-Containing Oxidoreductase