"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Descriptor ID |
D004249
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MeSH Number(s) |
G05.200
|
Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
|
Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1993 | 0 | 1 | 1 |
1996 | 0 | 1 | 1 |
1997 | 0 | 2 | 2 |
2000 | 0 | 1 | 1 |
2002 | 2 | 2 | 4 |
2003 | 2 | 1 | 3 |
2004 | 1 | 2 | 3 |
2005 | 1 | 3 | 4 |
2006 | 1 | 2 | 3 |
2007 | 0 | 3 | 3 |
2008 | 1 | 1 | 2 |
2009 | 1 | 2 | 3 |
2010 | 0 | 3 | 3 |
2011 | 1 | 0 | 1 |
2012 | 2 | 0 | 2 |
2013 | 1 | 1 | 2 |
2014 | 2 | 2 | 4 |
2015 | 1 | 5 | 6 |
2016 | 3 | 5 | 8 |
2017 | 2 | 3 | 5 |
2018 | 0 | 4 | 4 |
2019 | 2 | 2 | 4 |
2020 | 1 | 3 | 4 |
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Below are the most recent publications written about "DNA Damage" by people in Profiles.
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Zhang Y, Houchen CW, Li M. Attenuating DNA damage response and immunosuppression radiosensitizes pancreatic cancer. EBioMedicine. 2022 Feb; 76:103822.
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Byrum JN, Hoolehan WE, Simpson DA, Rodgers W, Rodgers KK. Full length RAG2 expression enhances the DNA damage response in pre-B cells. Immunobiology. 2021 05; 226(3):152089.
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Rajan A, Nadhan R, Latha NR, Krishnan N, Warrier AV, Srinivas P. Deregulated estrogen receptor signaling and DNA damage response in breast tumorigenesis. Biochim Biophys Acta Rev Cancer. 2021 01; 1875(1):188482.
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Neizer-Ashun F, Bhattacharya R. Reality CHEK: Understanding the biology and clinical potential of CHK1. Cancer Lett. 2021 01 28; 497:202-211.
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Patidar PL, Viera T, Morales JC, Singh N, Motea EA, Khandelwal M, Fattah FJ. XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. Sci Rep. 2020 08 28; 10(1):14253.
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Dang TT, Morales JC. Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress. Int J Mol Sci. 2020 Jun 15; 21(12).
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Mehta M, Griffith J, Panneerselvam J, Babu A, Mani J, Herman T, Ramesh R, Munshi A. Regorafenib sensitizes human breast cancer cells to radiation by inhibiting multiple kinases and inducing DNA damage. Int J Radiat Biol. 2021; 97(8):1109-1120.
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Dwivedi SKD, Shameer K, Dey A, Mustafi SB, Xiong X, Bhattacharya U, Neizer-Ashun F, Rao G, Wang Y, Ivan C, Yang D, Dudley JT, Xu C, Wren JD, Mukherjee P, Bhattacharya R. KRCC1: A potential therapeutic target in ovarian cancer. FASEB J. 2020 02; 34(2):2287-2300.
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Wise HC, Iyer GV, Moore K, Temkin SM, Gordon S, Aghajanian C, Grisham RN. Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models. Sci Rep. 2019 12 11; 9(1):18882.
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Thadathil N, Hori R, Xiao J, Khan MM. DNA double-strand breaks: a potential therapeutic target for neurodegenerative diseases. Chromosome Res. 2019 12; 27(4):345-364.