"Dishevelled Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
Below are MeSH descriptors whose meaning is more general than "Dishevelled Proteins".
Below are MeSH descriptors whose meaning is more specific than "Dishevelled Proteins".
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Below are the most recent publications written about "Dishevelled Proteins" by people in Profiles.
The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol. 2016 07; 18(7):752-764.
Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun. 2015 Mar 16; 6:6380.