"MRE11 Homologue Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
| Descriptor ID |
D000076228
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| MeSH Number(s) |
D08.811.277.352.335.350.650 D08.811.277.352.335.375.813 D08.811.277.352.355.325.600 D08.811.277.352.365.290.250 D12.776.157.687.495 D12.776.260.539 D12.776.660.720.495
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| Concept/Terms |
MRE11 Homologue Protein- MRE11 Homologue Protein
- Homologue Protein, MRE11
- MRE11A Protein
- Meiotic Recombination 11 Homolog 1 Protein
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Below are MeSH descriptors whose meaning is more general than "MRE11 Homologue Protein".
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Below are the most recent publications written about "MRE11 Homologue Protein" by people in Profiles.