Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.
| Descriptor ID |
D019860
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| MeSH Number(s) |
D08.811.913.696.620.682.725.800.315 D12.776.624.664.700.128
|
| Concept/Terms |
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- p56 lck
- Proto-Oncogene Protein c-lck
- Protein c-lck, Proto-Oncogene
- Proto Oncogene Protein c lck
- c-lck, Proto-Oncogene Protein
- Proto-Oncogene Protein lck
- Protein lck, Proto-Oncogene
- Proto Oncogene Protein lck
- lck, Proto-Oncogene Protein
- lck Kinase
- Kinase, lck
- Protein Tyrosine Kinase p56(lck)
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Below are MeSH descriptors whose meaning is more general than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".
This graph shows the total number of publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in this website by year, and whether "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 3 | 3 |
| 1998 | 1 | 0 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in Profiles.
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Distal Lck Promoter-Driven Cre Shows Cell Type-Specific Function in Innate-like T Cells. Immunohorizons. 2021 09 28; 5(9):772-781.
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Membrane-cytoskeleton interactions in cholesterol-dependent domain formation. Essays Biochem. 2015; 57:177-87.
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SHP-1 dephosphorylates 3BP2 and potentially downregulates 3BP2-mediated T cell antigen receptor signaling. FEBS J. 2006 May; 273(10):2195-205.
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Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37. J Biol Chem. 2004 Sep 17; 279(38):39975-81.
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A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science. 2003 Sep 19; 301(5640):1725-8.
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Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat Immunol. 2001 Feb; 2(2):165-71.
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Effects of geldanamycin, a heat-shock protein 90-binding agent, on T cell function and T cell nonreceptor protein tyrosine kinases. J Immunol. 2000 Mar 15; 164(6):2915-23.
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Lck activity controls CD4/CD8 T cell lineage commitment. Immunity. 2000 Mar; 12(3):313-22.
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Modular folding and evidence for phosphorylation-induced stabilization of an hsp90-dependent kinase. J Biol Chem. 1998 Apr 03; 273(14):8475-82.
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L-selectin activates the Ras pathway via the tyrosine kinase p56lck. Proc Natl Acad Sci U S A. 1996 Dec 24; 93(26):15376-81.