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Karla K Rodgers

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMicrobiology & Immunology
AddressBMSB 0832
940 Stanton L Young Blvd
Oklahoma City OK 73104
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    Collapse Research 
    Collapse research activities and funding
    R01AI168175     (RODGERS, KARLA K)Aug 7, 2023 - Jul 31, 2027
    NIH
    DNA sequence selectivity in conventional and aberrant V(D)J recombination
    Role: Principal Investigator
    R21AI156351     (RODGERS, KARLA K)Nov 23, 2020 - Oct 31, 2023
    NIH
    Deciphering DNA sequence selectivity in V(D)J recombination
    Role: Principal Investigator
    R21AI128137     (RODGERS, KARLA K)Jun 1, 2017 - May 31, 2020
    NIH
    Nuclear export-dependent functions of RAG2 in the DNA damage response system
    Role: Principal Investigator
    R03AI126001     (RODGERS, KARLA K)Jun 13, 2016 - May 31, 2019
    NIH
    Single cell visualization of the V(D)J recombinase complex
    Role: Principal Investigator
    R21AI094141     (RODGERS, KARLA K)Aug 25, 2012 - Jul 31, 2015
    NIH
    Regulation of the VDJ recombinase during genotoxic stress
    Role: Principal Investigator
    R01AI054467     (RODGERS, KARLA K)Sep 15, 2003 - Dec 31, 2009
    NIH
    Protein-DNA Interactions in V(D)J Recombination
    Role: Principal Investigator
    F32GM016039     (RODGERS, KARLA K)Oct 14, 1994
    NIH
    CYSTEINE-RICH REGION OF RAG-1
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hoolehan W, Harris JC, Rodgers KK. Molecular Mechanisms of DNA Sequence Selectivity in V(D)J Recombination. ACS Omega. 2023 Sep 26; 8(38):34206-34214. PMID: 37779976; PMCID: PMC10536018.
      Citations:    
    2. Chowdhury AA, Rodgers K, Godbole NM, Awasthi S. Stability and structure-activity relationship of the SPA4 peptide under ambient and stressed conditions of lung injury. RSC Adv. 2023 Jun 15; 13(27):18864-18877. PMID: 37350860; PMCID: PMC10282593.
      Citations:    
    3. Hoolehan W, Harris JC, Byrum JN, Simpson DA, Rodgers KK. An updated definition of V(D)J recombination signal sequences revealed by high-throughput recombination assays. Nucleic Acids Res. 2022 Nov 11; 50(20):11696-11711. PMID: 36370096; PMCID: PMC9723617.
      Citations: 5     Fields:    Translation:Cells
    4. Chowdhury AA, Godbole NM, Chataut N, Kosanke S, Rodgers K, Awasthi S. Effects of SPA4 peptide on lipopolysaccharide-disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury. Physiol Rep. 2022 07; 10(13):e15353. PMID: 35838161.
      Citations: 2     Fields:    Translation:HumansAnimals
    5. Awasthi S, Kumar G, Ramani V, Awasthi V, Rodgers KK, Xie J, Beierle J, Kyere-Davies G, Singh B, Rahman N, Chowdhury AA, Chataut N. Mechanism of Anti-Inflammatory Activity of TLR4-Interacting SPA4 Peptide. Immunohorizons. 2021 08 24; 5(8):659-674. PMID: 34429343.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Byrum JN, Hoolehan WE, Simpson DA, Rodgers W, Rodgers KK. Full length RAG2 expression enhances the DNA damage response in pre-B cells. Immunobiology. 2021 05; 226(3):152089. PMID: 33873062.
      Citations: 1     Fields:    Translation:HumansCells
    7. Rodgers W, Byrum JN, Simpson DA, Hoolehan W, Rodgers KK. RAG2 localization and dynamics in the pre-B cell nucleus. PLoS One. 2019; 14(5):e0216137. PMID: 31075127.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    8. Rodgers KK. Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures. Trends Biochem Sci. 2017 01; 42(1):72-84. PMID: 27825771.
      Citations: 10     Fields:    Translation:AnimalsCells
    9. Ding XQ, Thapa A, Ma H, Xu J, Elliott MH, Rodgers KK, Smith ML, Wang JS, Pittler SJ, Kefalov VJ. The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility. J Biol Chem. 2016 Apr 15; 291(16):8721-34. PMID: 26893377.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Byrum JN, Zhao S, Rahman NS, Gwyn LM, Rodgers W, Rodgers KK. An interdomain boundary in RAG1 facilitates cooperative binding to RAG2 in formation of the V(D)J recombinase complex. Protein Sci. 2015 May; 24(5):861-73. PMID: 25676158.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    11. Rodgers W, Byrum JN, Sapkota H, Rahman NS, Cail RC, Zhao S, Schatz DG, Rodgers KK. Spatio-temporal regulation of RAG2 following genotoxic stress. DNA Repair (Amst). 2015 Mar; 27:19-27. PMID: 25625798.
      Citations: 8     Fields:    Translation:HumansCells
    12. Awasthi S, Anbanandam A, Rodgers KK. Structure of a TLR4-interacting SPA4 peptide. RSC Adv. 2015; 5(35):27431-27438. PMID: 25870755.
      Citations: 7     
    13. Sheikh MO, Schafer CM, Powell JT, Rodgers KK, Mooers BH, West CM. Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry. 2014 Mar 18; 53(10):1657-69. PMID: 24506136.
      Citations: 16     Fields:    Translation:AnimalsCells
    14. Chakraborty D, Rodgers KK, Conley SM, Naash MI. Structural characterization of the second intra-discal loop of the photoreceptor tetraspanin RDS. FEBS J. 2013 Jan; 280(1):127-38. PMID: 23121719.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Chollangi S, Mather T, Rodgers KK, Ash JD. A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem. 2012 Sep 21; 287(39):32848-59. PMID: 22829597.
      Citations: 9     Fields:    Translation:HumansCells
    16. Gupta VK, Rajala A, Rodgers KK, Rajala RV. Mechanism involved in the modulation of photoreceptor-specific cyclic nucleotidegated channel by the tyrosine kinase adapter protein Grb14. Protein Cell. 2011 Nov; 2(11):906-17. PMID: 22180090.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    17. Nikolaeva O, Moiseyev G, Rodgers KK, Ma JX. Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. Biochem J. 2011 Jun 15; 436(3):591-7. PMID: 21446919.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Arbuckle JL, Rahman NS, Zhao S, Rodgers W, Rodgers KK. Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding. BMC Biochem. 2011 May 20; 12:23. PMID: 21599978.
      Citations: 11     Fields:    Translation:AnimalsCells
    19. Matveev AV, Fitzgerald JB, Xu J, Malykhina AP, Rodgers KK, Ding XQ. The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change. Biochemistry. 2010 Mar 02; 49(8):1628-39. PMID: 20088482.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    20. Gwyn LM, Peak MM, De P, Rahman NS, Rodgers KK. A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity. J Mol Biol. 2009 Jul 31; 390(5):863-78. PMID: 19500590.
      Citations: 10     Fields:    Translation:Cells
    21. Zhao S, Gwyn LM, De P, Rodgers KK. A non-sequence-specific DNA binding mode of RAG1 is inhibited by RAG2. J Mol Biol. 2009 Apr 03; 387(3):744-58. PMID: 19232525.
      Citations: 20     Fields:    Translation:AnimalsCells
    22. De P, Zhao S, Gwyn LM, Godderz LJ, Peak MM, Rodgers KK. Thermal dependency of RAG1 self-association properties. BMC Biochem. 2008 Jan 30; 9:5. PMID: 18234093.
      Citations: 2     Fields:    Translation:Cells
    23. Rahman NS, Godderz LJ, Stray SJ, Capra JD, Rodgers KK. DNA cleavage of a cryptic recombination signal sequence by RAG1 and RAG2. Implications for partial V(H) gene replacement. J Biol Chem. 2006 May 05; 281(18):12370-80. PMID: 16531612.
      Citations: 11     Fields:    Translation:HumansCells
    24. Zhu G, Zhai P, He X, Wakeham N, Rodgers K, Li G, Tang J, Zhang XC. Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5. EMBO J. 2004 Oct 13; 23(20):3909-17. PMID: 15457209.
      Citations: 6     Fields:    Translation:HumansCells
    25. Terzyan S, Wakeham N, Zhai P, Rodgers K, Zhang XC. Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain. Proteins. 2004 Aug 01; 56(2):277-84. PMID: 15211511.
      Citations: 1     Fields:    Translation:HumansCells
    26. De P, Rodgers KK. Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1. Immunol Rev. 2004 Aug; 200:70-82. PMID: 15242397.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    27. De P, Peak MM, Rodgers KK. DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated. Mol Cell Biol. 2004 Aug; 24(15):6850-60. PMID: 15254250.
      Citations: 9     Fields:    Translation:AnimalsCells
    28. He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J. Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins. Biochemistry. 2003 Oct 28; 42(42):12174-80. PMID: 14567678.
      Citations: 38     Fields:    Translation:HumansCells
    29. Godderz LJ, Rahman NS, Risinger GM, Arbuckle JL, Rodgers KK. Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase. Nucleic Acids Res. 2003 Apr 01; 31(7):2014-23. PMID: 12655019.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    30. Peak MM, Arbuckle JL, Rodgers KK. The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer. J Biol Chem. 2003 May 16; 278(20):18235-40. PMID: 12644467.
      Citations: 12     Fields:    Translation:AnimalsCells
    31. Arbuckle JL, Fauss LA, Simpson R, Ptaszek LM, Rodgers KK. Identification of two topologically independent domains in RAG1 and their role in macromolecular interactions relevant to V(D)J recombination. J Biol Chem. 2001 Oct 05; 276(40):37093-101. PMID: 11479318.
      Citations: 20     Fields:    Translation:AnimalsCells
    32. Rodgers KK, Villey IJ, Ptaszek L, Corbett E, Schatz DG, Coleman JE. A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2. Nucleic Acids Res. 1999 Jul 15; 27(14):2938-46. PMID: 10390537.
      Citations: 29     Fields:    Translation:AnimalsCells
    33. Bellon SF, Rodgers KK, Schatz DG, Coleman JE, Steitz TA. Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster. Nat Struct Biol. 1997 Jul; 4(7):586-91. PMID: 9228952.
      Citations: 40     Fields:    Translation:Cells
    34. Rodgers KK, Bu Z, Fleming KG, Schatz DG, Engelman DM, Coleman JE. A zinc-binding domain involved in the dimerization of RAG1. J Mol Biol. 1996 Jul 05; 260(1):70-84. PMID: 8676393.
      Citations: 37     Fields:    Translation:Cells
    35. Rodgers KK, Coleman JE. DNA binding and bending by the transcription factors GAL4(62*) and GAL4(149*). Protein Sci. 1994 Apr; 3(4):608-19. PMID: 8003979.
      Citations: 6     Fields:    Translation:Cells
    36. Rodgers KK, Sligar SG. Mapping electrostatic interactions in macromolecular associations. J Mol Biol. 1991 Oct 20; 221(4):1453-60. PMID: 1658337.
      Citations: 8     Fields:    Translation:AnimalsCells
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