"Mad2 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.
| Descriptor ID |
D064246
|
| MeSH Number(s) |
D12.776.167.313 D12.776.660.526
|
| Concept/Terms |
Mad2 Proteins- Mad2 Proteins
- Mad2 Mitotic Arrest Deficient-like 1 Proteins
|
Below are MeSH descriptors whose meaning is more general than "Mad2 Proteins".
Below are MeSH descriptors whose meaning is more specific than "Mad2 Proteins".
This graph shows the total number of publications written about "Mad2 Proteins" by people in this website by year, and whether "Mad2 Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mad2 Proteins" by people in Profiles.
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miR-125b promotes cell death by targeting spindle assembly checkpoint gene MAD1 and modulating mitotic progression. Cell Death Differ. 2013 Mar; 20(3):430-42.
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Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice. Carcinogenesis. 2009 Sep; 30(9):1469-74.
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Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol. 2005 Jun 21; 15(12):1078-89.
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The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes. Nat Genet. 2005 Jul; 37(7):756-60.
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The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev. 2003 Jan 01; 17(1):101-14.
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Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. J Cell Biol. 2002 Sep 02; 158(5):841-7.
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Differences in spindle association of the mitotic checkpoint protein Mad2 in mammalian spermatogenesis and oogenesis. Dev Biol. 2000 Sep 01; 225(1):112-23.
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Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events. J Cell Biol. 1998 Jun 15; 141(6):1393-406.
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Cell cycle checkpoints: arresting progress in mitosis. Bioessays. 1997 Mar; 19(3):193-7.