DNA Breaks, Double-Stranded
"DNA Breaks, Double-Stranded" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently.
| Descriptor ID |
D053903
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| MeSH Number(s) |
G05.200.210.220
|
| Concept/Terms |
DNA Breaks, Double-Stranded- DNA Breaks, Double-Stranded
- Break, Double-Stranded DNA
- Breaks, Double-Stranded DNA
- DNA Break, Double-Stranded
- DNA Breaks, Double Stranded
- Double-Stranded DNA Break
- Double Stranded DNA Break
- Double-Strand DNA Breaks
- Break, Double-Strand DNA
- Breaks, Double-Strand DNA
- DNA Break, Double-Strand
- DNA Breaks, Double-Strand
- Double Strand DNA Breaks
- Double-Strand DNA Break
- Double-Stranded DNA Breaks
- Double Stranded DNA Breaks
|
Below are MeSH descriptors whose meaning is more general than "DNA Breaks, Double-Stranded".
Below are MeSH descriptors whose meaning is more specific than "DNA Breaks, Double-Stranded".
This graph shows the total number of publications written about "DNA Breaks, Double-Stranded" by people in this website by year, and whether "DNA Breaks, Double-Stranded" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 2 | 3 |
| 2016 | 1 | 3 | 4 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 2 | 3 |
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Below are the most recent publications written about "DNA Breaks, Double-Stranded" by people in Profiles.
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DNA Double-Strand Break Accumulation in Alzheimer's Disease: Evidence from Experimental Models and Postmortem Human Brains. Mol Neurobiol. 2021 Jan; 58(1):118-131.
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XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. Sci Rep. 2020 08 28; 10(1):14253.
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Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress. Int J Mol Sci. 2020 Jun 15; 21(12).
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DNA double-strand breaks: a potential therapeutic target for neurodegenerative diseases. Chromosome Res. 2019 12; 27(4):345-364.
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Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding. J Biol Chem. 2019 08 16; 294(33):12459-12471.
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The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes. J Biol Chem. 2017 05 19; 292(20):8459-8471.
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Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures. Trends Biochem Sci. 2017 01; 42(1):72-84.
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A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence. Redox Biol. 2017 04; 11:30-37.
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Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB). Sci Rep. 2016 05 25; 6:26631.
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The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair. Nucleic Acids Res. 2016 Feb 29; 44(4):1718-31.