"Receptor, trkA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
| Descriptor ID |
D020917
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.660 D12.776.543.750.630.496 D12.776.543.750.750.400.550.550
|
| Concept/Terms |
Receptor, trkA- Receptor, trkA
- Proto-Oncogene Protein trk
- Proto Oncogene Protein trk
- trk, Proto-Oncogene Protein
- gp140(c-TRK)
- trk Proto-Oncogene Protein
- Proto-Oncogene Protein, trk
- trk Proto Oncogene Protein
- NTRK1 Receptor
- Receptor, NTRK1
- Proto-Oncogene Products c-trk
- Proto Oncogene Products c trk
- c-trk, Proto-Oncogene Products
- c-trk Protein
- c trk Protein
- gp140 c-trk
- c-trk, gp140
- gp140 c trk
- p140-trkA
- p140 trkA
- trk1 Transforming Tryrosine Kinase
- Neurotrophic Tyrosine Kinase Receptor Type 1
- trkA Receptor
- Receptor, Neurotrophic Tyrosine Kinase Type 1
|
Below are MeSH descriptors whose meaning is more general than "Receptor, trkA".
Below are MeSH descriptors whose meaning is more specific than "Receptor, trkA".
This graph shows the total number of publications written about "Receptor, trkA" by people in this website by year, and whether "Receptor, trkA" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, trkA" by people in Profiles.
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Molecular characterization of cancers with NTRK gene fusions. Mod Pathol. 2019 01; 32(1):147-153.
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BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations. Oncotarget. 2017 Jun 20; 8(25):39945-39962.
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The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. J Biol Chem. 2016 Nov 11; 291(46):23895-23905.
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Biogenesis and function of the NGF/TrkA signaling endosome. Int Rev Cell Mol Biol. 2015; 314:239-57.
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Paradoxical effect of TrkA inhibition in Alzheimer's disease models. J Alzheimers Dis. 2014; 40(3):605-617.
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Kinomic profiling approach identifies Trk as a novel radiation modulator. Radiother Oncol. 2012 Jun; 103(3):380-7.
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Rab22 controls NGF signaling and neurite outgrowth in PC12 cells. Mol Biol Cell. 2011 Oct; 22(20):3853-60.
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Nerve growth factor-mediated neurite outgrowth via regulation of Rab5. Mol Biol Cell. 2007 Apr; 18(4):1375-84.
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C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1. J Immunol. 2004 Jun 01; 172(11):6961-8.