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An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis.
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An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis.
An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis. Nat Commun. 2020 07 17; 11(1):3612.
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PubMed
subject areas
Animals
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Bile Acids and Salts
Bile Acids and Salts
Cell Line
Cell Line
Cholesterol
Cholesterol
Cholesterol 7-alpha-Hydroxylase
Cholesterol 7-alpha-Hydroxylase
Diet, Western
Diet, Western
Disease Models, Animal
Disease Models, Animal
Fibroblast Growth Factors
Fibroblast Growth Factors
Hep G2 Cells
Hep G2 Cells
Humans
Humans
Hypercholesterolemia
Hypercholesterolemia
Ileum
Ileum
Liver
Liver
Male
Male
Mice
Mice
Organic Anion Transporters, Sodium-Dependent
Organic Anion Transporters, Sodium-Dependent
Symporters
Symporters