"Liver X Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nuclear receptors that bind OXYSTEROLS and function as heterodimers with RETINOID X RECEPTORS. They have important functions in regulating cholesterol homeostasis, ENERGY METABOLISM; INFLAMMATION; and the immune response.
| Descriptor ID |
D000071518
|
| MeSH Number(s) |
D12.776.260.531 D12.776.826.194
|
| Concept/Terms |
Liver X Receptors- Liver X Receptors
- Nuclear Oxysterol Receptors
- Oxysterol Receptors, Nuclear
- Liver X Receptor
Liver X Receptor Alpha- Liver X Receptor Alpha
- Liver X Receptor-Alpha
- NR1H3 Protein
- LXRalpha Protein
- Nuclear Orphan Receptor LXR-Alpha
- Nuclear Orphan Receptor LXR Alpha
- Oxysterols Receptor LXR-Alpha
- LXR-Alpha, Oxysterols Receptor
- Oxysterols Receptor LXR Alpha
- Nuclear Receptor Subfamily 1, Group H, Member 3
- LXR-Alpha Protein
- LXR Alpha Protein
Liver X Receptor Beta- Liver X Receptor Beta
- Liver X Receptor-Beta
- Nuclear Receptor Subfamily 1, Group H, Member 2
- Oxysterols Receptor LXR-Beta
- LXR-Beta, Oxysterols Receptor
- Oxysterols Receptor LXR Beta
- LXRbeta Protein
- NR1H2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Liver X Receptors".
Below are MeSH descriptors whose meaning is more specific than "Liver X Receptors".
This graph shows the total number of publications written about "Liver X Receptors" by people in this website by year, and whether "Liver X Receptors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 2 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Liver X Receptors" by people in Profiles.
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Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRa signaling. Cell Rep. 2025 Apr 22; 44(4):115527.
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Fasting and fasting-mimicking treatment activate SIRT1/LXRa and alleviate diabetes-induced systemic and microvascular dysfunction. Diabetologia. 2021 07; 64(7):1674-1689.
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Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes. JCI Insight. 2020 07 09; 5(13).
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Liver X receptor-a activation enhances cholesterol secretion in lactating mammary epithelium. Am J Physiol Endocrinol Metab. 2019 06 01; 316(6):E1136-E1145.
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Activation of LXR?/? by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer. BMC Cancer. 2018 Dec 10; 18(1):1232.
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Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1-Mediated Cholesterol Removal. Am J Pathol. 2019 02; 189(2):405-425.
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Defective cholesterol metabolism in haematopoietic stem cells promotes monocyte-driven atherosclerosis in rheumatoid arthritis. Eur Heart J. 2018 06 14; 39(23):2158-2167.
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Glucose availability controls adipogenesis in mouse 3T3-L1 adipocytes via up-regulation of nicotinamide metabolism. J Biol Chem. 2017 11 10; 292(45):18556-18564.
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The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor. EBioMedicine. 2017 Aug; 22:181-190.
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A multigenic approach to evaluate genetic variants of PLCE1, LXRs, MMPs, TIMP, and CYP genes in gallbladder cancer predisposition. Tumour Biol. 2014 Sep; 35(9):8597-606.